ObjectiveTo evaluate the clinical value of gastrointestinal contrast-enhanced ultrasonography（CEUS）in evaluating gastric emptying in patients with functional dyspepsia（FD）of different clinical types and severity before and aftertreatment.MethodsTotally 128 patients with FD who were admitted to our hospital were involved as FD group and furtherdivided into epigastric pain syndrome（EPS）subgroup（n=68）and postprandial discomfort syndrome（PDS）subgroup（n=60）.Inthe same period

65 healthy adults were involved as the control group.The total gastric cavity volume（TGCV）and gastric emptyingrate of all subjects were measured when fasting

0 min（immediately after the end of the trial meal）

30 min

60 min

90 min

120 min after trial meal

and the change trend of TGCV and gastric emptying rate with time increased in the two groups werecompared.After conventional clinical treatment with FD

the 120-min gastric emptying rate after the meal were calculated againto compare the gastric emptying rates of the two subgroups and the patients with different severity of FD before and after thetreatment.ResultsThe postprandial TGCV of both FD group and control group showed a decreasing trend

but the change ofTGCV in the control group was significantly greater than that in FD group（P<0.05）.The gastric emptying rate in both groupswere increased with time increased（P<0.05）

but the gastric emptying rate in the FD group at each time point were lower thanthose in the control group（all P<0.05）.The 120-min gastric emptying rate of patients in the EPS subgroup before treatment was significantly higher than that in the PDS subgroup（P<0.05）

and that in the mild patients was significantly higher than that in themoderate and severe patients

there were statistically significant between each other（all P<0.05）.After treatment

the 120-mingastric emptying rate in the PDS subgroup was significantly higher than that in the EPS subgroup（P<0.05）

there was nosignificant difference in FD patients with different severity degree.The 120-min gastric emptying rate after treatment in PDSsubgroup and EPS subgroup

as well as in FD patients with each severity degree

were higher than that before treatment

and thedifferences were statistically significant（all P<0.05）.ConclusionGastrointestinal CEUS can be used to evaluate FD accuratelyand objectively.Gastrointestinal CEUS shows that PDS patients has better therapeutic effect than EPS patients

and FD patientswith different severity could be effectively treated.