Research progress in gene transfection mediated by ultrasound-targeted microbubble destruction technology

ZHANG Yue; ZHOU Houren; XIN Ying; LI Shihui; LIU Xiaoqi; LIU Zhijun

doi:10.16245/j.cnki.issn1008-6978.2020.07.017

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Research progress in gene transfection mediated by ultrasound-targeted microbubble destruction technology

更新时间：2021-10-08

- Research progress in gene transfection mediated by ultrasound-targeted microbubble destruction technology
- Journal of Clinical Ultrasound in Medicine Vol. 22, Issue 7, Pages: 523-525(2020)
- 作者机构：
  
  中国医科大学附属盛京医院超声科
- 作者简介：
- 基金信息：
- DOI：10.16245/j.cnki.issn1008-6978.2020.07.017
  CLC： R450
- Published：2020，
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[1]张月,周厚妊,辛莹,李诗慧,刘小奇,刘治军.超声靶向微泡破坏技术介导基因转染的研究进展[J].临床超声医学杂志,2020,22(07):523-525.

ZHANG Yue, ZHOU Houren, XIN Ying, et al. Research progress in gene transfection mediated by ultrasound-targeted microbubble destruction technology. [J]. Journal of Clinical Ultrasound in Medicine 22(7):523-525(2020)
[1]张月,周厚妊,辛莹,李诗慧,刘小奇,刘治军.超声靶向微泡破坏技术介导基因转染的研究进展[J].临床超声医学杂志,2020,22(07):523-525. DOI： 10.16245/j.cnki.issn1008-6978.2020.07.017.

ZHANG Yue, ZHOU Houren, XIN Ying, et al. Research progress in gene transfection mediated by ultrasound-targeted microbubble destruction technology. [J]. Journal of Clinical Ultrasound in Medicine 22(7):523-525(2020) DOI： 10.16245/j.cnki.issn1008-6978.2020.07.017.

摘要

基因转染技术的高速发展不仅革新了生物学和医学许多基本问题的研究

也推动了诊断和治疗的进步。基因作为核酸类生物活性大分子

极易在体内降解

因此传递基因的载体尤为重要。超声靶向微泡破坏（UTMD）技术利用超声波和微泡之间的相互作用

以及其产生的生物学效应

使微泡携基因进行转染

并与多种载体联合应用

为疾病的治疗提供了有效手段。本文就UTMD技术介导基因转染的研究进展进行综述。

Abstract

The rapid development of gene transfection technology has not only revolutionized the research of many basic problems in biology and medicine

but also promoted the progress of diagnosis and treatment.As a biologically active macromolecule of nucleic acids

the gene is easily degraded in the body

so the carrier for gene delivery is particularly important.Ultrasound-targeted microbubble destruction technology（UTMD） utilizes the interaction between ultrasound and microbubbles and the biological effects it produces to enable microbubbles to carry genes for gene transfection and can be used in combination with a variety of vectors.The treatment of a variety of diseases provides an effective means.This article reviews the recent advances in gene transfection by ultrasound-targeted microbubble destruction.

关键词

超声靶向微泡破坏技术基因转染微泡载体

Keywords

Ultrasound-targeted microbubble destructionGene transfectionMicrobubbleCarrier

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Related Author

刘治军

刘小奇

李诗慧

辛莹

周厚妊

张月

徐亚丽

李露

Related Institution

Shengjing Hospital of China Medical University

陆军军医大学第二附属医院

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重庆医科大学附属第二医院超声科，超声分子影像重庆市重点实验室

中国人民解放军中部战区总医院超声科

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