Research progress of focused ultrasound thermal ablation and focused ultrasound-induced opening of the blood-brain barrier in the treatment of cerebral diseases

LUO Kaixuan; LIN Aijin; CHEN Moxuan; ZHANG Liuying; YI Shasha; AO Lijuan

doi:10.16245/j.cnki.issn1008-6978.2020.06.015

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Research progress of focused ultrasound thermal ablation and focused ultrasound-induced opening of the blood-brain barrier in the treatment of cerebral diseases

更新时间：2021-10-08

- Research progress of focused ultrasound thermal ablation and focused ultrasound-induced opening of the blood-brain barrier in the treatment of cerebral diseases
- Journal of Clinical Ultrasound in Medicine Vol. 22, Issue 6, Pages: 448-451(2020)
- 作者机构：
  
  昆明医科大学康复学院
- 作者简介：
- 基金信息：
- DOI：10.16245/j.cnki.issn1008-6978.2020.06.015
  CLC： R742;R445.1
- Published：2020，
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[1]罗凯旋,林爱金,陈茉弦,张留影,易沙沙,敖丽娟.聚焦超声热消融及开放血脑屏障治疗脑部疾病的研究进展[J].临床超声医学杂志,2020,22(06):448-451.

LUO Kaixuan, LIN Aijin, CHEN Moxuan, et al. Research progress of focused ultrasound thermal ablation and focused ultrasound-induced opening of the blood-brain barrier in the treatment of cerebral diseases. [J]. Journal of Clinical Ultrasound in Medicine 22(6):448-451(2020)
[1]罗凯旋,林爱金,陈茉弦,张留影,易沙沙,敖丽娟.聚焦超声热消融及开放血脑屏障治疗脑部疾病的研究进展[J].临床超声医学杂志,2020,22(06):448-451. DOI： 10.16245/j.cnki.issn1008-6978.2020.06.015.

LUO Kaixuan, LIN Aijin, CHEN Moxuan, et al. Research progress of focused ultrasound thermal ablation and focused ultrasound-induced opening of the blood-brain barrier in the treatment of cerebral diseases. [J]. Journal of Clinical Ultrasound in Medicine 22(6):448-451(2020) DOI： 10.16245/j.cnki.issn1008-6978.2020.06.015.

摘要

聚焦超声是一种新兴的非侵入式治疗方法。在特定参数下

聚焦超声可经颅骨对颅内组织进行热消融

也可联合微泡可逆地开放血脑屏障

提高药物疗效以治疗脑部疾病。目前

聚焦超声在治疗原发性震颤、帕金森病、精神病、脑肿瘤、神经病理性疼痛等脑部疾病方面取得了一定研究进展。本文就聚焦超声热消融及开放血脑屏障治疗脑部疾病的研究进展进行综述。

Abstract

As a novel non-invasive treatment method

focused ultrasound（FUS）can be used to treat brain diseases via thermal ablation of intracranial tissues under specific parameters transcranially.Combined with microbubbles

it can also be used to enhance the efficiency of drug delivery by opening the blood-brain barrier reversibly.Nowadays

Progress has been made in treatment of brain diseases such as essential tremor

Parkinson’s disease

psychosis

brain tumor and neuropathic pain with FUS.This article reviews the research progress of FUS thermal ablation and FUS-induced opening of the blood-brain barrier in the treatment of cerebral diseases.

关键词

聚焦超声热消融血脑屏障药物递送脑部疾病

Keywords

Focused ultrasoundThermal ablationBlood-brain barrierDrug deliveryBrain diseases

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Department of Ultrasound, Hospital of PLA

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