Clinical diagnostic value of qualitative and quantitative parameters of contrastenhanced ultrasonography in benign and malignant breast nodules

SUN Min; HU Xiaodan; YANG Zhaohui; LIU Hongmei; YU Ling; Xu Qing; XIAO Rong

doi:10.16245/j.cnki.issn1008-6978.2020.06.013

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Clinical diagnostic value of qualitative and quantitative parameters of contrastenhanced ultrasonography in benign and malignant breast nodules

更新时间：2021-10-08

- Clinical diagnostic value of qualitative and quantitative parameters of contrastenhanced ultrasonography in benign and malignant breast nodules
- Journal of Clinical Ultrasound in Medicine Vol. 22, Issue 6, Pages: 444-447(2020)
- 作者机构：
  
  西藏自治区政府驻成都办事处医院功能科
- 作者简介：
- 基金信息：
- DOI：10.16245/j.cnki.issn1008-6978.2020.06.013
  CLC： R737.9;R445.1
- Published：2020，
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[1]孙敏,胡晓丹,杨昭晖,刘红梅,余玲,徐晴,肖蓉.超声造影特征及定量参数鉴别诊断乳腺良恶性结节的临床价值[J].临床超声医学杂志,2020,22(06):444-447.

SUN Min, HU Xiaodan, YANG Zhaohui, et al. Clinical diagnostic value of qualitative and quantitative parameters of contrastenhanced ultrasonography in benign and malignant breast nodules. [J]. Journal of Clinical Ultrasound in Medicine 22(6):444-447(2020)
[1]孙敏,胡晓丹,杨昭晖,刘红梅,余玲,徐晴,肖蓉.超声造影特征及定量参数鉴别诊断乳腺良恶性结节的临床价值[J].临床超声医学杂志,2020,22(06):444-447. DOI： 10.16245/j.cnki.issn1008-6978.2020.06.013.

SUN Min, HU Xiaodan, YANG Zhaohui, et al. Clinical diagnostic value of qualitative and quantitative parameters of contrastenhanced ultrasonography in benign and malignant breast nodules. [J]. Journal of Clinical Ultrasound in Medicine 22(6):444-447(2020) DOI： 10.16245/j.cnki.issn1008-6978.2020.06.013.

摘要

目的探讨乳腺超声造影特征及定量参数对乳腺良恶性结节的鉴别诊断价值。方法选取经超声引导下活检或术后病理证实的乳腺结节233例

其中恶性95例

良性138例。应用超声造影检查乳腺病灶区域的定性指标和定量参数

对其进行单因素分析;筛选出差异有统计学意义的定性指标和定量参数进行二元Logistic回归分析

绘制受试者工作特征（ROC）曲线评价其对乳腺恶性结节的诊断效能。结果单因素分析结果显示

乳腺良恶性结节的增强强度、增强速度、增强后形态、增强后范围、增强后边界、有无毛刺、有无灌注缺损及峰值强度（Peak%）比较差异均有统计学意义（均P<0.05）;经Logistic回归分析优化后

其中增强后范围、有无灌注缺损、有无毛刺、增强后边界、增强后形态是诊断恶性结节的重要指标（均P<0.05）;Logistic回归模型即Logit（P）=-6.663-0.804×增强后范围+1.357×有无灌注缺损+2.267×有无毛刺+1.232×增强后边界+0.662×增强后形态

其预测乳腺恶性结节的准确率为81.5%

ROC曲线下面积为0.894

敏感性和特异性分别为81.1%、84.1%。结论应用超声造影特征如增强后范围增大、有灌注缺损或毛刺、增强后边界不清或形态不规则建立的Logistic回归模型

对诊断乳腺恶性结节具有较高的临床价值。

Abstract

ObjectiveTo explore the diagnostic value of qualitative and quantitative parameters of contrast-enhanced ultrasonography（CEUS）in differentiating benign and malignant breast nodules.MethodsTwo hundred and thirty-three cases of breast nodules confirmed by ultrasound-guided biopsy or pathology after operation were selected

including 95 cases of malignant nodules and 138 cases of benign nodules.The qualitative and quantitative parameters of CEUS in the breast lesions were observed

and univariate analysis was carried out. Statistically significant qualitative and quantitative parameters were screened for binary Logistic regression analysis

and receiver operating characteristic（ROC）curve was obtained to evaluate the efficacy of the parameters in the diagnosis of malignant nodules.Results Univariate analysis showed that CEUS enhancement intensity

enhancement speed

morphology

enhancement range

enhancement boundary

marginal burr

perfusion defect and peak intensity（Peak%）were statistically significant difference for the diagnosis of benign malignant breast nodules（all P<0.05）.Logistic regression analysis showed that the optimized diagnostic indexes and parameters were the enhanced range

perfusion defect

marginal burrs

the enhanced boundary and the enhanced morphology（all P<0.05）.The accuracy of Logistic regression model in predicting malignant breast nodules was 81.5%

the area under the ROC curve was 0.894

the sensitivity and specificity were 0.811 and 0.841

respectively.ConclusionThe CEUS features of breast

such as enlarged area

perfusion defect

marginal burr

unclear border and irregular shape are helpful to diagnose malignant breast nodules.

关键词

超声检查造影剂定性指标定量参数乳腺肿瘤良恶性

Keywords

UltrasonographyContrast agentQualitative indexQuantitative parametersBreast tumorbenign and malignant

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