Comparative study of transrectal three-dimensional contrast-enhanced tomographic ultrasound imaging and multi-parameter MRI in the diagnosis of prostate cancer

CHEN Ming; XU Jinyang; LV Guorong; HUANG Qingwen; LI Hongying; SHEN Haolin; YANG Shuping

doi:10.16245/j.cnki.issn1008-6978.2020.06.010

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Comparative study of transrectal three-dimensional contrast-enhanced tomographic ultrasound imaging and multi-parameter MRI in the diagnosis of prostate cancer

更新时间：2021-10-08

- Comparative study of transrectal three-dimensional contrast-enhanced tomographic ultrasound imaging and multi-parameter MRI in the diagnosis of prostate cancer
- Journal of Clinical Ultrasound in Medicine Vol. 22, Issue 6, Pages: 435-439(2020)
- 作者机构：
  
  1. 福建医科大学附属漳州市医院超声科
  2. 福建医科大学附属第二医院超声科
  3. 福建医科大学附属漳州市医院影像科
- 作者简介：
- 基金信息：
- DOI：10.16245/j.cnki.issn1008-6978.2020.06.010
  CLC： R445.1;R737.25
- Published：2020，
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[1]陈明,徐锦洋,吕国荣,黄庆文,李红婴,沈浩霖,杨舒萍.经直肠三维超声造影断层成像与多参数MRI诊断前列腺癌的对比研究[J].临床超声医学杂志,2020,22(06):435-439.

CHEN Ming, XU Jinyang, LV Guorong, et al. Comparative study of transrectal three-dimensional contrast-enhanced tomographic ultrasound imaging and multi-parameter MRI in the diagnosis of prostate cancer. [J]. Journal of Clinical Ultrasound in Medicine 22(6):435-439(2020)
[1]陈明,徐锦洋,吕国荣,黄庆文,李红婴,沈浩霖,杨舒萍.经直肠三维超声造影断层成像与多参数MRI诊断前列腺癌的对比研究[J].临床超声医学杂志,2020,22(06):435-439. DOI： 10.16245/j.cnki.issn1008-6978.2020.06.010.

CHEN Ming, XU Jinyang, LV Guorong, et al. Comparative study of transrectal three-dimensional contrast-enhanced tomographic ultrasound imaging and multi-parameter MRI in the diagnosis of prostate cancer. [J]. Journal of Clinical Ultrasound in Medicine 22(6):435-439(2020) DOI： 10.16245/j.cnki.issn1008-6978.2020.06.010.

摘要

目的比较经直肠三维超声造影断层成像（3D-CETRUS TUI）与多参数MRI（mp-MRI）对前列腺癌患者的诊断价值。方法前瞻性选取2017年4月至2019年3月在我院就诊的临床疑似前列腺癌患者164例

所有病例均行3D-CETRUS TUI及mp-MRI检查

并接受经直肠超声引导下经会阴前列腺12针系统穿刺活检术;以穿刺病理结果为金标准

比较两种诊断方法对不同PSA区间（4 ng/ml <PSA≤10 ng/ml、10 ng/ml<PSA≤20 ng/ml、PSA>20 ng/ml）前列腺癌的诊断效能。结果 3D-CETRUS TUI与mp-MRI对前列腺癌诊断敏感性分别为75.6%、85.6%

特异性分别为71.6%、81.1%

两者比较差异无统计学意义。4 ng/ml<PSA≤10 ng/ml时

3D-CETRUS TUI与mp-MRI对前列腺癌诊断敏感性分别为51.4%、74.3%

特异性分别为68.4%、81.6%

差异均有统计学意义（均P<0.05）;10 ng/ml<PSA≤20 ng/ml时

3D-CETRUS TUI与mp-MRI对前列腺癌诊断敏感性分别为76.1%、78.3%

特异性分别为78.3%、87.0%

差异均无统计学意义;PSA>20 ng/ml时

两种方法的特异性和敏感性均为100%。结论 3D-CETRUS TUI技术在对前列腺癌的诊断方面

尤其是当患者PSA>10 ng/ml时

能获得与mp-MRI相似的诊断结论;有望成为前列腺癌诊断及评估的又一重要影像学诊断方法。

Abstract

ObjectiveTo compare the diagnostic value of three-dimensional contrast-enhanced tomographicultrasound imaging（3 D-CETRUS TUI）and multi-parametric MRI（mp-MRI）in patients with prostate cancer.MethodsOnehundred and sixty-four patients with suspected prostate cancer in our hospital from April 2017 to March 2019 were included.Allcases underwent 3 D-CETRUS TUI

mp-MRI examination and transperineal prostate 12 needle system puncture under theguidance of transrectal ultrasound.According to the gold standard of puncture pathological results

the diagnostic efficiency of thetwo methods for prostate cancer with three different PSA level（4 ng/ml < PSA≤10 ng/ml

10 ng/ml <PSA≤20 ng/ml

PSA>20 ng/ml）were analyzed.ResultsThe sensitivity of 3 D-CETRUS TUI and mp-MRI for the diagnosis of prostate cancer were 75.6% and85.6%

the specificity were 71.6% and 81.1%

respectively.There were significant difference（both P<0.05）.The sensitivity of3 D-CETRUS TUI and mp-MRI for the diagnosis of prostate cancer with 4 ng/ml<PSA≤10 ng/ml were 51.4%

74.3%

and thespecificity were 68.4% and 81.6%

respectively.There were no significant difference.When 10 ng/ml<PSA≤20 ng/ml

the sensitivityof 3 D-CETRUS TUI and mp-MRI for the diagnosis of prostate cancer were 76.1%

78.3%

and the specificity were 78.3%% and87.0%

respectively.There were no significant difference.When PSA>20 ng/ml

the sensitivity and specificity of the two methodswere 100%.ConclusionWhen patients with PSA>10 ng/ml

3 D-CETRUS TUI can obtain similar diagnostic conclusions as mp-MRI

and it is more rapid and efficient

so it is expected to become another important imaging diagnosis method for thediagnosis and evaluation of prostate cancer.

关键词

超声检查三维经直肠造影剂超声断层成像多参数MRI前列腺癌前列腺癌特异抗原

Keywords

Ultrasonographythree-dimensionaltransrectalContrast agentTomographic ultrasound imagingMultiparameter MRIProstate cancerProstate cancer specific antigen

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