Evaluation of carotid elasticity in patients with severe preeclampsia using pulse wave velocity

ZHAO Xiaoyu; DOU Shuixiu; DING Linru; DU Yaqian; ZHANG Ying’an; HE Yinfang; XU Jianping

doi:10.16245/j.cnki.issn1008-6978.2020.06.005

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Evaluation of carotid elasticity in patients with severe preeclampsia using pulse wave velocity

更新时间：2021-10-13

- Evaluation of carotid elasticity in patients with severe preeclampsia using pulse wave velocity
- Journal of Clinical Ultrasound in Medicine Vol. 22, Issue 6, Pages: 415-419(2020)
- 作者机构：
  
  1. 山西医科大学第一医院超声影像科
  2. 山西医科大学第一医院妇产科
- 作者简介：
- 基金信息：
- DOI：10.16245/j.cnki.issn1008-6978.2020.06.005
  CLC： R714.244;R445.1
- Published：2020，
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[1]赵晓宇,窦水秀,丁琳茹,杜亚倩,张映安,何银芳,许建萍.应用脉搏波传导速度评估重度子痫前期患者颈动脉弹性[J].临床超声医学杂志,2020,22(06):415-419.

ZHAO Xiaoyu, DOU Shuixiu, DING Linru, et al. Evaluation of carotid elasticity in patients with severe preeclampsia using pulse wave velocity. [J]. Journal of Clinical Ultrasound in Medicine 22(6):415-419(2020)
[1]赵晓宇,窦水秀,丁琳茹,杜亚倩,张映安,何银芳,许建萍.应用脉搏波传导速度评估重度子痫前期患者颈动脉弹性[J].临床超声医学杂志,2020,22(06):415-419. DOI： 10.16245/j.cnki.issn1008-6978.2020.06.005.

ZHAO Xiaoyu, DOU Shuixiu, DING Linru, et al. Evaluation of carotid elasticity in patients with severe preeclampsia using pulse wave velocity. [J]. Journal of Clinical Ultrasound in Medicine 22(6):415-419(2020) DOI： 10.16245/j.cnki.issn1008-6978.2020.06.005.

摘要

目的探讨脉搏波传导速度（PWVβ）评估重度子痫前期（SPE）患者颈动脉弹性的临床价值。方法随机选取我院SPE患者64例（SPE组）和正常妊娠妇女31例（对照组）

两组均于产前、产后记录一般临床资料并行双侧颈总动脉超声检查;使用M型超声获取双侧颈总动脉中段收缩末期内径（Ds）、舒张末期内径（Dd）;使用血管内中膜定量分析（QIMT）技术获取双侧颈总动脉中段平均内中膜厚度（IMT）

计算PWVβ

并进行统计学分析。结果 SPE组产前检查时间为孕（32.29±4.18）周

产后复查时间为（21.79±5.03）周;对照组产前检查时间为孕（33.45±5.38）周

产后复查时间为（21.97±3.80）周

两组比较差异均无统计学意义。①组间比较:产前

SPE组体质量、体质量指数（BMI）、收缩压、舒张压、Ds、Dd、IMT及PWVβ均较对照组增加（均P<0.05）;产后

SPE组体质量、BMI、收缩压、舒张压、IMT及PWVβ均较对照组增加（均P<0.05）;②组内比较:SPE组产后体质量、BMI、Ds、Dd、PWVβ均较产前减低（均P<0.05）;对照组产后体质量、BMI、Ds、Dd均较产前减低（均P<0.05）

PWVβ呈减低趋势

但差异无统计学意义。与对照组产前后PWVβ变化值比较

SPE组产前后PWVβ变化值呈增加趋势

但差异无统计学意义。所有受试者及SPE组PWVβ与年龄、体质量、BMI、收缩压、舒张压、Ds及Dd均呈正相关（Rall=0.23、0.29、0.30、0.43、0.28、0.24、0.38;RSPE=0.20、0.26、0.27、0.33、0.17、0.20、0.34

均P<0.05）;其中Ds、Dd、收缩压及舒张压均为影响颈动脉PWVβ的独立危险因素（均P<0.01）。结论应用PWVβ可准确评估SPE患者颈动脉弹性;SPE患者产前PWVβ增加

颈动脉硬度增加

弹性功能已经受损;产后平均21.79周颈动脉弹性虽有明显恢复但未恢复至正常妊娠妇女产后同期状态

这与SPE患者产后Ds、Dd、收缩压及舒张压等恢复情况相关。

Abstract

ObjectiveTo explore the clinical value of pulse wave velocity（PWVβ）in evaluating the elasticity of carotid artery in patients with severe preeclampsia（SPE）.MethodsSixty-four patients with SPE（SPE group）and 31 women with normal pregnancy（control group）were randomly selected in our hospital. The general clinical data were recorded and bilateral common carotid artery ultrasound examination was performed in both groups antepartum and postpartum. The end systolic diameter（Ds）and end diastolic diameter（Dd）of bilateral common carotid artery were obtained by M-mode ultrasound.Mean intima-media thickness（IMT）in the middle segment of bilateral common carotid artery was obtained by quality intimamedia thickness（QIMT）technique

PWVβ was calculated for statistical analysis.ResultsIn SPE group

the prenatal examination was at（32.29 ± 4.18）gestational weeks and the postnatal review time was at（21.79 ± 5.03）weeks

and in control group

the prenatal examination was at（33.45±5.38）gestational weeks and the postnatal review time was at（21.97±3.80）weeks

there were no significant difference between the two groups.（1）Comparison between groups:before birth

the body mass

body mass index （BMI）

systolic pressure

diastolic pressure

IMT and PWVβ of the SPE group were all increased compared with the control group（all P<0.05）.After delivery（average 21.79 weeks）

body mass

BMI

systolic pressure

diastolic pressure

IMT and PWVβ of the SPE group were increased compared with the control group（all P<0.05）.（2） Comparison within the group:postpartum body mass

BMI

PWVβ of the SPE group were decreased compared with antepartum（all P<0.05）

after delivery

body mass

BMI

Ds and Dd were decreased in the control group（all P<0.05）

PWVβ showed a decreasing trend

but the difference was not statistical significance.Compared with the change of PWVβ value before and after delivery in the control group

the change of PWVβ value before and after delivery in the SPE group showed an increasing trend

but the difference was not statistically significant.PWVβ were positively correlated with age

body mass

BMI

systolic pressure

diastolic pressure

Ds and Dd in all subjects and SPE groups（Rall=0.23

0.29

0.30

0.43

0.28

0.24

0.38

RSPE=0.20

0.26

0.27

0.33

0.17

0.20

0.34

all P<0.05）. Ds

systolic pressure and diastolic pressure were independent risk factors for carotid PWVβ（all P=0.01）.ConclusionThe carotid artery elasticity can be evaluated by PWVβ.The increase of PWVβ shows that the prenatal carotid artery elasticity has been damaged in patients with SPE.Although the carotid artery elasticity has recovered significantly after the average 21.79 weeks postpartum

it has not recovered to the same postpartum state of women with normal pregnancy history.This is related to the recovery of postpartum Ds

systolic pressure and diastolic pressure in SPE patients.

关键词

脉搏波传导速度子痫前期重度颈动脉弹性

Keywords

Pulse wave velocityPreeclampsiasevereCarotid elasticity

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Related Institution

Beijing Chaoyang Hospital,Capital Medical University,Department of Ultrasound medicine

联系电话：15911057918 Email：zhuying80128@com

Department of Ultrasonography,the First Hospital of Shanxi Medical University

山西医科大学第一医院

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