ObjectiveTo quantitatively evaluate the early changes of left ventricular（LV）global systolic function inpatients with type-2 diabetes mellitus（T2 DM）by three-dimensional speckle tracking imaging（3 D-STI）.MethodsEightyT2 DM patients（case group）were selected and divided into two groups according to the left ventricular ejection fraction（LVEF）:50 patients in DM1 group（LVEF ≥50%） and 30 patients in DM2 group（LVEF<50%）. And 42 healthy volunteers（controlgroup）were selected in the control group. The general clinical date

conventional ultrasonic parameters（LA

LVIDd

IVSd

LVPWd

LVEF

E/A）and 3 D-STI parameters

including global systolic peak longitudinal strain（GLS）

global radial strain（GRS）

global circumferential strain（GCS）and global area strain（GAS）of left ventricle in the three groups were measured andcompared.ResultsThere were significant differences in LA

IVSd

LVPWd

E/A among the groups（all P<0.05）.Compared withcontrol group

GLS

GCS and GAS in DM1 group were decreased significantly（-14.254±3.005）% vs.（-17.530±3.358）%

（-23.117±4.441）% vs.（-28.982±6.029）%

（-37.064±5.231）% vs.（-41.594±7.569）%

while GRS was increased significantly（-28.151±11.190）% vs.（21.629±12.972）%

there were significantly differences（all P<0.05）.GLS

GCS and GAS in DM2 groupwere significantly decreased（all P<0.05）

while GRS had no difference.In addition

GLS

GCS

GRS and GAS in DM2 group weresignificantly lower than those in DM1 group（all P<0.05）.Conclusion3 D-STI can be used to detect early left ventricularsystolic dysfunction in T2 DM patients

and is a reliable method to evaluate early abnormal heart function in diabetic patients.