Objective To investigate the value of real-time tissue elastography（RTE） guided needle stimulation of myofascial trigger points（MTrPs） in the treatment of myofascial pain syndrome（MPS）.Methods A total of 60 patients with trapezius muscle MPS admitted to our hospital were randomly divided into RTE group and traditional stimulation group（each group 30 patients） according to the random number table method.The difference of elastic score of MTrPs and pain scores before and after treatment were compared between the two groups.The patients were followed up for 1 year.The treatment effects and long-term prognosis of the two groups were compared.Results There was statistically significant difference in the elasticity scores of MTrPs between the two groups after treatment（P<0.05）.After treatment

the visual analogue scale（VAS） and pain assessment index（PRI） of the RTE group（3.02±0.54

3.34±0.62） were significantly lower than those in the traditional stimulation group（3.89±0.36

3.76±0.34）

and the differences were statistically significant（both P<0.05）.The follow-up results showed that the apparent efficiency and cumulative no-recurrence rate of the RTE group were 86.7% and 93.33%.The apparent efficiency and cumulative no-recurrence rate of the traditional stimulation were 60.0% and 57.1%

and the differences were statistically significant（both P<0.05）.Conclusion The therapeutic effect and prognosis of RTE guided needle stimulation of MTrPs are significantly better than traditional palpation needle stimulation

which has important clinical value.