Objective To explore the correlation between marginal zone enhancement features and quantitative parameters of contrast-enhanced ultrasound and immunochemical indexes of breast cancer.Methods A total of 76 female breast cancer patients（76 lesions） confirmed by postoperative pathology and immunohistochemistry were selected.All patients underwent contrast-enhanced ultrasonography to observe the enhancement characteristics of the marginal zone of breast cancer lesions

and obtain quantitative parameters of time-intensity curve（TIC） including peak intensity

basic intensity

gradient

ascending branch slope

peak time and area under the curve.The correlation of contrast-enhanced ultrasound parameters and quantitative parameters of contrast-enhanced ultrasound and immunochemical indexes such as estrogen receptor（ER）

progesterone receptor（PR）

human epidermal growth factor receptor-2（HER-2）

and proliferating cell nuclear antigen（Ki-67）were analyzed.Results The enhancement of the marginal zone of breast ultrasound lesion was correlated with ER and Ki-67 positive expression.Perforator enhancement was correlated with HER-2 positive expression.The range enlargement after angiography were correlated with the positive expressions of ER

HER-2 and Ki-67

edge enhancement was correlated with Ki-67 positive expression

and the differences were statistically significant（all P<0.05）.The peak intensity

the area under the TIC curve and the gradient were positively correlated with the positive expression of Ki-67.The peak time was negatively correlated with the positive expression of ER and PR

and the differences were statistically significant（all P<0.05）.Conclusion The marginal zone contrast enhancement features and quantitative parameters of contrast-enhanced ultrasound of breast cancer has certain correlation with ER

PR

HER-2 and Ki-67

which can provide a reference for the selection of preoperative precise treatment methods for breast cancer patients.