ObjectiveTo compare the changes of Young’s modulus of transitional and peripheral zone of prostate in benign prostatic hyperplasia patients after medicine treatment

and to investigate the clinical value of real-time shear wave elastography in the evaluation of the therapeutic effect.MethodsA total of 175 patients with benign prostatic hyperplasia who underwent transrectal shear wave elastography were selected.Young’s modulus of transitional zone and peripheral zone of prostate were measured by real-time shear wave elastography before and after medicine treatment. Young’s modulus of transitional zone and peripheral zone of prostate were compared and their correlation with international prostate symptom score（IPSS）

quality of life（QOL）score

maximum flow rate of urine（Qmax）

prostate volume（PV）

post void residual（PVR）were evaluated.ResultsThe mean Young’s modulus of prostate transitional zone and peripheral zone were from（60.17±5.86）kPa、（24.82±3.03）kPa to（40.23±5.84）、（15.14±2.93）kPa before and after medicine treatment

respectively

with statistical significance（both P<0.05）.Young’s modulus of transitional zone showed a significant correlation with IPSS

QOL

Qmax

PV

PVR（r=0.69

0.84

-0.73

0.53

0.74

all P<0.05）

and Young’s modulus of prostate peripheral zone showed a weak correlation with IPSS

QOL

Qmax

PV

PVR（r=0.58

0.72

-0.58

0.44

0.55

all P<0.05）.ConclusionShear wave elastography could provide the information of prostate hardness before and after medicine treatment.It is an effective way to evaluate the treatment value and has good clinical application value.