ObjectiveTo evaluate left ventricular systolic function in hemodialysis patients with valvular calcification（VC）by three-dimensional speckle tracking imaging（3 D-STI）.MethodsFifty-five hemodialysis patients with normal left ventricular ejection fraction（LVEF）were divided into VC group（26 cases）and NVC group（29 cases）.30 healthy volunteers were selected as control group.All groups were underwent conventional echocardiography and 3 D-STI.Interventricular septum thickness（IVST）

left ventricular posterior wall end diastolic thickness（LVPWT）

left ventricular end systolic diameter（LVESD）

left ventricular end diastolic diameter（LVEDD）

LVEF

left ventricular global peak longitudinal strain（GLS）

global circumferential strain（GCS）

global area strain（GAS）

global radial strain（GRS）and left ventricular mass（LVM）were measured

and left ventricular myocardial mass index（LVMI）was calculated.The differences of the above parameters in each group were analyzed.ResultsCompared with the control group

IVSd

LVPWd and LVMI in VC group and NVC group were significantly increased

GLS

GCS

GAS and GRS were significantly decreased（all P<0.05）

while LVEDD

LVESD and LVEF had no significant difference.Compared with NVC group

IVSd

LVPWd and LVMI were significantly increased in VC group

GLS

GCS

GAS and GRS significantly decreased（all P<0.05）.ConclusionCardiac systolic function is impaired in hemodialysis patients

left ventricular remodeling and myocardial systolic function are more impaired in VC patients than those in NVC patients.3 D-STI can accurately evaluate the left ventricular systolic function in hemodialysis patients with VC

which has better clinical application value.