ObjectiveTo investigate the value of color Doppler ultrasound in the evaluation of hemodynamics of posterior ophthalmic artery in diabetic retinopathy patients with nonproliferative macular edema.MethodsThirty patients（46 eyes） with nonproliferative macular edema of type 2 diabetes mellitus（case group） and 30 patients（60 eyes） with nonproliferative retinopathy of type 2 diabetes mellitus（control group）were selected. The blood flow parameters of central retinal artery（CRA）

ophthalmic artery（OA）and posterior ciliary artery（PCA）were measured by color Doppler ultrasound.The diagnostic value of blood flow parameters for diabetic macular edema was analyzed by drawing the ROC curve.ResultsThe blood flow spectrums of CRA and PCA in the case group were lower and blunt than those in the control group

and the blood flow spectrums of OA in the case group were similar to those in the control group.The systolic blood flow velocity（PSV）

end diastolic blood flow velocity（EDV）and resistance index（RI）of CRA in the case group were lower than those in the control group

and the differences were statistically significant（all P<0.05）.PSV and EDV of PCA in the case group were lower than those in the control group（both P<0.05）

RI of PCA in the case group had no significant difference compared with that in the control group.There was no significant difference in all parameters of OA between the case group and the control group.The optimal cutoff values of PSV

EDV and RI of CRA were 7.655 cm/s

2.925 cm/s and 0.645

respectively

the corresponding sensitivity and specificity were 80.0%

60.7%

63.8% and 76.1%

76.1% and 70.0%

respectively

the area under ROC curve were 0.783

0.720 and 0.692

respectively.The optimal cutoff values of PSV

EDV of PCA were 8.75 cm/s

2.56 cm/s

respectively

the corresponding sensitivity and specificity were 75.0%

81.3% and 61.4%

60.9%

respectively

the area under ROC curve were 0.536

0.533

respectively.ConclusionColor Doppler ultrasound can monitor the hemodynamic changes of the retrobulbar artery in diabetic patients with nonproliferative macular edema

which provide a reliable basis for early clinical treatment.