慢传输性便秘结肠Cajal间质细胞减少与细胞凋亡的关系

童卫东; 李朝阳; 刘宝华; 熊仁平; 刘苹; 张连阳; 张胜本

doi:10.16016/j.1000-5404.2004.12.008

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慢传输性便秘结肠Cajal间质细胞减少与细胞凋亡的关系

更新时间：2026-01-09

- 慢传输性便秘结肠Cajal间质细胞减少与细胞凋亡的关系
- Journal of Army Medical University Vol. 26, Issue 12, (2004)
- 作者机构：
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- DOI：10.16016/j.1000-5404.2004.12.008
  CLC： R656.9
- Online First：30 June 2004，
  
  Published：2004
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童卫东,李朝阳,刘宝华,熊仁平,刘苹,张连阳,张胜本,慢传输性便秘结肠Cajal间质细胞减少与细胞凋亡的关系[J].陆军军医大学学报(原第三军医大学学报),2004,26(12):0-.

童卫东, 李朝阳, 刘宝华, et al. 慢传输性便秘结肠Cajal间质细胞减少与细胞凋亡的关系[J]. Journal of Army Medical University, 2004, 26(12).
童卫东,李朝阳,刘宝华,熊仁平,刘苹,张连阳,张胜本,慢传输性便秘结肠Cajal间质细胞减少与细胞凋亡的关系[J].陆军军医大学学报(原第三军医大学学报),2004,26(12):0-. DOI：10.16016/j.1000-5404.2004.12.008

童卫东, 李朝阳, 刘宝华, et al. 慢传输性便秘结肠Cajal间质细胞减少与细胞凋亡的关系[J]. Journal of Army Medical University, 2004, 26(12). DOI： 10.16016/j.1000-5404.2004.12.008.

摘要

目的　探讨慢传输性便秘 (slowtransitconstipation

STC)结肠Cajal间质细胞 (interstitialcellsofCajal

ICC)减少是否与细胞凋亡有关。方法　收集 12例STC患者和 8例对照组乙状结肠标本

用免疫组化方法检测ICC分布情况

用原位末端标记法 (TUNEL)检测结肠壁黏膜层、黏膜下层和肌层的原位细胞凋亡情况

记数凋亡指数

半定量分析。结果　ICC分布于结肠肌层

包括黏膜下环肌层表面、环肌层、肌间神经丛、纵肌层四个区域

STC乙状结肠上述四个区域ICC分布均明显减少。原位细胞凋亡检测发现黏膜层和黏膜下层细胞凋亡明显增多 (P =0 .0 0 2 )

而肌层和肌间神经丛与对照组无显著差异。结论　STC患者乙状结肠ICC减少可能与凋亡无关。

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