内皮细胞生长因子诱导大鼠血管内皮细胞增殖过程中FKBP12的表达

王耀辉; 杨成明; 王旭开; 刘光耀; 石伟彬; 张晔

doi:10.16016/j.1000-5404.2003.24.017

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内皮细胞生长因子诱导大鼠血管内皮细胞增殖过程中FKBP12的表达

更新时间：2026-01-09

- 内皮细胞生长因子诱导大鼠血管内皮细胞增殖过程中FKBP12的表达
- Journal of Army Medical University Vol. 25, Issue 24, (2003)
- 作者机构：
- 作者简介：
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- DOI：10.16016/j.1000-5404.2003.24.017
  CLC： R329.2
- Online First：30 December 2003，
  
  Published：2003
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王耀辉,杨成明,王旭开,刘光耀,石伟彬,张晔,内皮细胞生长因子诱导大鼠血管内皮细胞增殖过程中FKBP12的表达[J].陆军军医大学学报(原第三军医大学学报),2003,25(24):0-.

王耀辉, 杨成明, 王旭开, et al. 内皮细胞生长因子诱导大鼠血管内皮细胞增殖过程中FKBP12的表达[J]. Journal of Army Medical University, 2003, 25(24).
王耀辉,杨成明,王旭开,刘光耀,石伟彬,张晔,内皮细胞生长因子诱导大鼠血管内皮细胞增殖过程中FKBP12的表达[J].陆军军医大学学报(原第三军医大学学报),2003,25(24):0-. DOI：10.16016/j.1000-5404.2003.24.017

王耀辉, 杨成明, 王旭开, et al. 内皮细胞生长因子诱导大鼠血管内皮细胞增殖过程中FKBP12的表达[J]. Journal of Army Medical University, 2003, 25(24). DOI： 10.16016/j.1000-5404.2003.24.017.

摘要

目的　探讨内皮细胞生长因子 (Endothelialcellgrowthfactor

ECGF)诱导的血管内皮细胞 (Vascularendothelialcell

VEC)增殖过程中FK5 0 6结合蛋白 12 (FK5 0 6bindingprotein 12

FKBP12 )表达的变化

为VEC的鉴定提供新的方法。方法　培养大鼠VEC并传代。倒置显微镜下观察其在ECGF作用下的增殖情况

检测Ⅷ因子相关抗原、FKBP12和不同时期FKBP12mRNA水平的表达。结果　VEC表达FKBP12 ;VEC传代后第 4天FKBP12mRNA表达水平达到最高

6～ 8d下降。结论　FKBP12既可作为VEC的标志物

又可反映VEC的增殖情况

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Related Institution

Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Provmce

Department of Orthopedics, the Second Affiliated Hospital of Chongqing Medical University

Department of Pathology, Second Affiliated Hospital, Army Medical University (Third Military Medical University)

Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University

Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Southwest Medical University

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