重庆地区人群GSTT1和GSTM1基因多态性与结直肠癌易感性研究

黄萍; 周紫垣; 刘晋祎; 马恒太; 周燕虹; 葛海燕; 余佩武; ToshiroTakezaki; 曹佳

doi:10.16016/j.1000-5404.2003.19.013

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重庆地区人群GSTT1和GSTM1基因多态性与结直肠癌易感性研究

更新时间：2026-01-09

- 重庆地区人群GSTT1和GSTM1基因多态性与结直肠癌易感性研究
- Journal of Army Medical University Vol. 25, Issue 19, (2003)
- 作者机构：
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- DOI：10.16016/j.1000-5404.2003.19.013
  CLC： R735.3
- Online First：15 October 2003，
  
  Published：2003
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黄萍,周紫垣,刘晋祎,马恒太,周燕虹,葛海燕,余佩武,ToshiroTakezaki,曹佳,重庆地区人群GSTT1和GSTM1基因多态性与结直肠癌易感性研究[J].陆军军医大学学报(原第三军医大学学报),2003,25(19):0-.

黄萍, 周紫垣, 刘晋祎, et al. 重庆地区人群GSTT1和GSTM1基因多态性与结直肠癌易感性研究[J]. Journal of Army Medical University, 2003, 25(19).
黄萍,周紫垣,刘晋祎,马恒太,周燕虹,葛海燕,余佩武,ToshiroTakezaki,曹佳,重庆地区人群GSTT1和GSTM1基因多态性与结直肠癌易感性研究[J].陆军军医大学学报(原第三军医大学学报),2003,25(19):0-. DOI：10.16016/j.1000-5404.2003.19.013

黄萍, 周紫垣, 刘晋祎, et al. 重庆地区人群GSTT1和GSTM1基因多态性与结直肠癌易感性研究[J]. Journal of Army Medical University, 2003, 25(19). DOI： 10.16016/j.1000-5404.2003.19.013.

摘要

目的　了解谷胱苷肽转硫酶GSTT1和GSTT1基因多态性与结直肠癌易感性的关系。方法　采用多重PCR技术对 82例病例和 82例对照GSTT1、GSTM1基因型进行了检测和分析。结果　GSTM1基因缺失频率在病例组和对照组之间有显著差异 (P 0 .0 1

OR =2 .464

95 %CI =1.3 11～ 4.63 3 )。GSTM1和GSTT1基因同时缺失的个体在病例组和对照组之间有差异 (P 0 .0 5

OR =2 .476

95 %CI =1.0 46～ 5 .861)。结论　GSTM1基因缺失可能是结直肠癌发生的易感基因型。GSTT1基因单独缺失与结直肠癌发生的危险性不相关

但在GSTM1缺失基础上再伴有GSTT1基因缺失的个体

患结直肠癌的危险性将会增加

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