热应激对培养血管内皮细胞增殖的影响

罗晓凤; 罗向东; 王仙园

doi:10.16016/j.1000-5404.2002.11.028

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热应激对培养血管内皮细胞增殖的影响

更新时间：2026-01-09

- 热应激对培养血管内皮细胞增殖的影响
- Journal of Army Medical University Vol. 24, Issue 11, (2002)
- 作者机构：
- 作者简介：
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- DOI：10.16016/j.1000-5404.2002.11.028
  CLC： R644
- Online First：30 November 2002，
  
  Published：2002
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罗晓凤,罗向东,王仙园,热应激对培养血管内皮细胞增殖的影响[J].陆军军医大学学报(原第三军医大学学报),2002,24(11):0-.

罗晓凤, 罗向东, 王仙园. 热应激对培养血管内皮细胞增殖的影响[J]. Journal of Army Medical University, 2002, 24(11).
罗晓凤,罗向东,王仙园,热应激对培养血管内皮细胞增殖的影响[J].陆军军医大学学报(原第三军医大学学报),2002,24(11):0-. DOI：10.16016/j.1000-5404.2002.11.028

罗晓凤, 罗向东, 王仙园. 热应激对培养血管内皮细胞增殖的影响[J]. Journal of Army Medical University, 2002, 24(11). DOI： 10.16016/j.1000-5404.2002.11.028.

摘要

目的　探讨热应激条件下血管内皮细胞增殖变化的特点及相关机制。方法　以血管内皮细胞株ECV3 0 4受热 43℃、2h为热应激实验模型

观察血管内皮细胞的细胞间粘附分子 (ICAM 1)、分化抑制因子 1(Id1)、P16及P2 1的蛋白表达变化

3 H标记胸腺嘧啶核苷酸 (3 H TdR)掺入法测定细胞DNA的合成。结果　热应激后血管内皮细胞ICAM 1表达增强

Id1表达受抑制

P16、P2 1蛋白的表达增强。3 H TdR掺入实验显示热应激可显著抑制血管内皮细胞的DNA合成。结论　热应激可以活化血管内皮细胞

抑制细胞增殖

从而改变增殖与分化的协调关系

并可能进而影响创伤后组织细胞的修复

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