肝素对透明质酸酶不同表达水平的人乳腺癌细胞侵袭力的影响

王小毅; 任国胜; 石远; 汪毅; 姚榛祥

doi:10.16016/j.1000-5404.2002.10.042

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肝素对透明质酸酶不同表达水平的人乳腺癌细胞侵袭力的影响

更新时间：2026-01-09

- 肝素对透明质酸酶不同表达水平的人乳腺癌细胞侵袭力的影响
- Journal of Army Medical University Vol. 24, Issue 10, (2002)
- 作者机构：
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- DOI：10.16016/j.1000-5404.2002.10.042
  CLC： R737.9
- Online First：30 October 2002，
  
  Published：2002
- 稿件说明：
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王小毅,任国胜,石远,汪毅,姚榛祥,肝素对透明质酸酶不同表达水平的人乳腺癌细胞侵袭力的影响[J].陆军军医大学学报(原第三军医大学学报),2002,24(10):0-.

王小毅, 任国胜, 石远, et al. 肝素对透明质酸酶不同表达水平的人乳腺癌细胞侵袭力的影响[J]. Journal of Army Medical University, 2002, 24(10).
王小毅,任国胜,石远,汪毅,姚榛祥,肝素对透明质酸酶不同表达水平的人乳腺癌细胞侵袭力的影响[J].陆军军医大学学报(原第三军医大学学报),2002,24(10):0-. DOI：10.16016/j.1000-5404.2002.10.042

王小毅, 任国胜, 石远, et al. 肝素对透明质酸酶不同表达水平的人乳腺癌细胞侵袭力的影响[J]. Journal of Army Medical University, 2002, 24(10). DOI： 10.16016/j.1000-5404.2002.10.042.

摘要

目的　探讨透明质酸酶 (Hyaluronidase

Hyase)与肝素对肿瘤侵袭潜力的影响。方法　通过体外实验测定肿瘤细胞穿透Matrigel(人工基底膜 )的潜力。结果　 6株表达不同水平Hyase的人乳腺癌细胞侵袭潜力存在明显差异

Hyase高表达细胞株 (Hyase0 .1mU L)强于Hyase低表达细胞株 (Hyase 0 .1mU L) (P 0 .0 5 ) ;肝素处理后

无论Hyase高表达或低表达细胞株的侵袭潜力均明显降低 (P 0 .0 5 )

其侵袭潜力与肝素存在量效关系。结论　Hyase与肿瘤侵袭潜力有关

肝素能抑制肿瘤的侵袭。

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