Effects of Clinical Pathway of Drug Therapy on Management of Prophylactic Use of Proton Pump Inhibitors in Head and Neck Surgery During Perioperative Period

DONG Yueyan; XIE Yue; HAN Furong; ZHANG Chao

doi:10.14009/j.issn.1672-2124.2023.02.027

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Effects of Clinical Pathway of Drug Therapy on Management of Prophylactic Use of Proton Pump Inhibitors in Head and Neck Surgery During Perioperative Period

更新时间：2023-04-14

- Effects of Clinical Pathway of Drug Therapy on Management of Prophylactic Use of Proton Pump Inhibitors in Head and Neck Surgery During Perioperative Period
- Issue 2, Pages: 253-256(2023)
- 作者机构：
  
  首都医科大学附属北京同仁医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2023.02.027
  CLC： R969.3
- Published：2023，
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DONG Yueyan, XIE Yue, HAN Furong, et al. Effects of Clinical Pathway of Drug Therapy on Management of Prophylactic Use of Proton Pump Inhibitors in Head and Neck Surgery During Perioperative Period. [J]. (2):253-256(2023)
DOI：

DONG Yueyan, XIE Yue, HAN Furong, et al. Effects of Clinical Pathway of Drug Therapy on Management of Prophylactic Use of Proton Pump Inhibitors in Head and Neck Surgery During Perioperative Period. [J]. (2):253-256(2023) DOI： 10.14009/j.issn.1672-2124.2023.02.027.

摘要

目的：探讨药物治疗临床路径管理在头颈外科围手术期预防性使用质子泵抑制剂（PPI）管理中的作用。方法：选取2021年4—9月该院头颈外科出院患者作为管理前组；选取2021年10月至2022年3月该院头颈外科出院患者作为管理后组，采用药物治疗临床路径管理，针对头颈外科围手术期预防性使用PPI中存在的问题，药师与医师联合制定围手术期预防性应用PPI的药物治疗临床路径。通过调查管理前后患者围手术期PPI的用药指征和用药疗程等，对PPI的应用情况进行对比分析。结果：管理后，头颈外科围手术期预防性使用PPI的用药指征合理率由管理前的72.90%（191/262）提高至82.03%（105/128）

PPI使用率由管理前的30.57%（262/857）降至12.04%（128/1 063）

PPI使用强度由管理前的24.59 DDDs/（100人·d）降至10.49 DDDs/（100人·d）

差异均有统计学意义（P＜0.05）。结论：路径化管理模式可以促进头颈外科围手术期PPI的合理应用，为临床合理用药提供参考。

Abstract

OBJECTIVE: To explore the role of clinical pathway of drug therapy on management of prophylactic use of proton pump inhibitors（PPI） during perioperative period in head and neck surgery. METHODS: Patients discharged from the department of head and neck surgery of the hospital from Apr. to Sept. 2021 were selected as the pre-management group

and patients discharged from the department of head and neck surgery of the hospital from Oct. 2021 to Mar. 2022 were selected as the post-management group. Clinical pathway management of drug therapy was used to solve the problems in perioperative prophylactic use of PPI in the department of head and neck surgery. Pharmacists and clinicians jointly formulated the clinical pathway of drug therapy for perioperative prophylactic use of PPI. By investigating the indications and treatment courses of PPI before and after clinical pathway of drug therapy management in patients with head and neck surgery

the use of PPI was compared and analyzed. RESULTS: After management

the rational rate of perioperative prophylactic use of PPI in the department of head and neck surgery increased from 72.90%（191/262） to 82.03%（105/128）

and the use rate of PPI decreased from 30.57%（262/857） to 12.04%（128/1 063）

the use intensity of PPI decreased from 24.59 DDDs/（100 persons·d） to 10.49 DDDs/（100 persons·d）

the differences were statistically significant（P<0.05）. CONCLUSIONS: The pathway management model can promote the rational use of PPI in the head and neck surgery during perioperative period

and provide reference for clinical rational drug use.

关键词

药物治疗临床路径头颈外科围手术期质子泵抑制剂

Keywords

Clinical therapyClinical pathwayHead and neck surgeryPerioperative periodProton pump inhibitors

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