Domestic and Foreign Literature of Adverse Drug Reactions Induced by Tigecycline

ZHOU Xuanping; REN Junli; LU Ruqi; ZHENG Bin; PENG Fangchen

doi:10.14009/j.issn.1672-2124.2023.02.024

您当前的位置：

首页 >

文章列表页 >

Domestic and Foreign Literature of Adverse Drug Reactions Induced by Tigecycline

更新时间：2023-04-14

- Domestic and Foreign Literature of Adverse Drug Reactions Induced by Tigecycline
- Issue 2, Pages: 241-244(2023)
- 作者机构：
  
  1. 山西医科大学药学院
  2. 山西省人民医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2023.02.024
  CLC： {G353};R978.1
- Published：2023，
扫描看全文
ZHOU Xuanping, REN Junli, LU Ruqi, et al. Domestic and Foreign Literature of Adverse Drug Reactions Induced by Tigecycline. [J]. (2):241-244(2023)
DOI：

ZHOU Xuanping, REN Junli, LU Ruqi, et al. Domestic and Foreign Literature of Adverse Drug Reactions Induced by Tigecycline. [J]. (2):241-244(2023) DOI： 10.14009/j.issn.1672-2124.2023.02.024.

摘要

目的：探讨替加环素致药品不良反应（ADR）发生的特点及规律，为临床合理用药提供参考。方法：检索中国知网、维普数据库、万方数据库、PubMed、Web of Sciene和Embase等数据库中2005年1月至2022年8月发表的替加环素致ADR的个案报道，进行统计分析。结果：共纳入替加环素致ADR相关文献91篇，提取病例108例，其中男性68例，女性37例，性别不详3例；患者年龄主要为≥60岁（61例，占56.48%）;患者原患疾病主要为肺部感染及腹腔感染。替加环素致ADR的发生时间为给药后10 min至给药后2.5个月，大多数ADR发生于给药后7 d内（72例，占66.67%）。替加环素所致ADR累及多个器官和（或）系统，共219例次，其中消化系统损害（105例次，占47.95%）最为常见，其次为血液系统损害（77例次，占35.16%）。大多数发生ADR的患者经停药或积极对症治疗后，1周内症状均有好转（68例，占62.96%）。结论：替加环素所致ADR可累及多个器官和（或）系统，临床表现多样，用药期间应加强替加环素致ADR的认识与监测，以减少或避免ADR的发生，保障患者安全用药。

Abstract

OBJECTIVE: To probe into the characteristics and regularity of adverse drug reactions（ADR） induced by tigecycline

so as to provide reference for clinical rational medication. METHODS: Case reports of ADR induced by tigecycline published from Jan. 2005 to Aug. 2022 were retrieved from CNKI

VIP

Wanfang Data

PubMed

Web of Sciene and Embase. RESULTS: Totally 91 studies related to ADR induced by tigecycline were enrolled

including 108 patients

including 68 males

37 females and 3 unknown gender; patients were mainly aged ≥60 years（61 cases

56.48%）; patients’ primary diseases were mainly pulmonary infection and abdominal infection. The onset time of ADR induced by tigecycline ranged from 10 min after administration to 2.5 months after administration

with most ADR occurred within 7 d after administration（72 cases

66.67%）. ADR induced by tigecycline had involved multiple organs and（or） systems

totally 219 case-times

with digestive system damage（105 case-times

47.95%） being the most common

followed by hematologic system damage（77 case-times

35.16%）. Most patients who developed ADR were improved in symptoms within 1 week after drug withdrawal or receiving symptomatic treatment（68 cases

62.96%）. CONCLUSIONS: ADR induced by tigecycline can involve multiple organs and/or systems

with diverse clinical manifestations

the awareness and monitoring of ADR induced by tigecycline should be strengthened during medication to reduce or avoid the occurrence of ADR

and to ensure safe medication for patients.

关键词

替加环素药品不良反应文献分析

Keywords

TigecyclineAdverse drug reactionsLiterature analysis

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Comparative Analysis on Adverse Drug Reactions Between Ibuprofen and Acetaminophen

Literature Analysis of Adverse Drug Reactions and Drug Interaction of Tacrolimus

Literature Analysis of Adverse Drug Reactions Induced by Biphenyl Dimethyl Dicarboxylate

Analysis of Literature on Case Reports of Adverse Drug Reactions Induced by Montelukast Sodium in Children

Comparative Analysis on Adverse Drug Reactions of Domestic and Imported Iodixanol Injection

Related Author

GU Tongtong

ZHANG Hang

CHENG Chuhao

HUANG Beibei

LIU Dongxue

CHEN Di

WANG Yang

ZHANG Bihua

Related Institution

Institution of National Drug Clinical Trails, the Affiliated Hospital of Xuzhou Medical University

School of Pharmacy, Nanjing Medical University

Dept.of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Dept.of Clinical Pharmacy, Jinshan Hospital of Fudan University

Dept.of Pharmacy,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Science,Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation

⁰