Interaction Between Cyclosporine and Statins in the Treatment of Primary Nephrotic Syndrome

SONG Yao; GUO Heng; YANG Hongge; LI Xingang

doi:10.14009/j.issn.1672-2124.2023.02.022

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Interaction Between Cyclosporine and Statins in the Treatment of Primary Nephrotic Syndrome

更新时间：2023-04-14

- Interaction Between Cyclosporine and Statins in the Treatment of Primary Nephrotic Syndrome
- Issue 2, Pages: 234-236(2023)
- 作者机构：
  
  首都医科大学附属北京友谊医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2023.02.022
  CLC： R969.2
- Published：2023，
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SONG Yao, GUO Heng, YANG Hongge, et al. Interaction Between Cyclosporine and Statins in the Treatment of Primary Nephrotic Syndrome. [J]. (2):234-236(2023)
DOI：

SONG Yao, GUO Heng, YANG Hongge, et al. Interaction Between Cyclosporine and Statins in the Treatment of Primary Nephrotic Syndrome. [J]. (2):234-236(2023) DOI： 10.14009/j.issn.1672-2124.2023.02.022.

摘要

目的：了解该院原发性肾病综合征患者他汀类药物的使用情况，探讨所用的各类他汀类药物与环孢素可能存在的药物相互作用，为临床合理选药提供参考。方法：回顾性分析2022年1—6月该院门诊诊断为原发性肾病综合征患者的他汀类药物使用情况；利用Lexicomp药物相互作用数据库以及药品说明书，对所用他汀类药物的种类及其与环孢素可能存在的药物相互作用进行对比分析。结果：2022年1—6月，该院原发性肾病综合征患者使用的他汀类药物主要包括普伐他汀、氟伐他汀、辛伐他汀、阿托伐他汀和瑞舒伐他汀；其中，药品说明书“禁忌”项中明确列出禁止与环孢素合用的有辛伐他汀和瑞舒伐他汀。在Lexicomp数据库中，与环孢素相互作用为D等级的药物有普伐他汀、氟伐他汀和瑞舒伐他汀；与环孢素相互作用为X等级的药物为辛伐他汀和阿托伐他汀。结论：在原发性肾病综合征的治疗中，环孢素与他汀类药物存在相互作用，文献报道与药品说明书并不完全一致，医师在决策时需综合考量，选择普伐他汀和氟伐他汀可能更理想。

Abstract

OBJECTIVE: To investigate the application of statins in patients with primary nephrotic syndrome in this hospital

and to probe into the possible drug interactions between various types of statins and cyclosporine

so as to provide reference for rational clinical drug selection. METHODS: The application of statins in patients diagnosed with primary nephrotic syndrome in outpatient department in this hospital from Jan. to Jun. 2022 was retrospectively analyzed; the categories of statins used and their possible drug interactions with cyclosporine were compared and analyzed by using the Lexicomp drug interaction database and dispensatory. RESULTS: From Jan. to Jun. 2022

the main statins used by patients with primary nephrotic syndrome in this hospital included pravastatin

fluvastatin

simvastatin

atorvastatin and rosuvastatin; among them

simvastatin and rosuvastatin were definitely prohibited in combination with cyclosporine in the “contraindications” of the dispensatory. In the Lexicomp database

the drugs with D-class interactions with cyclosporine were pravastatin

fluvastatin and resulvastatin; the drugs with X-class interaction with cyclosporine were simvastatin and atorvastatin. CONCLUSIONS: In the treatment of primary nephrotic syndrome

there are interactions between cyclosporine and statins

and the literature reports do not fully agree with the dispensatory; physicians need to take a comprehensive consideration when making decisions

choosing pravastatin and fluvastatin may be more desirable.

关键词

原发性肾病综合征环孢素他汀类药物药物相互作用

Keywords

Primary nephrotic syndromeCyclosporineStatinsDrug interactions

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