Efficacy of Xuanfei Tongluo Formula in the Treatment of Children with Mycoplasma Pneumoniae Pneumonia and Its Effects on Inflammatory Factors, sIgA, hBD2 and CAL

DI Wenwen; LU Ying; ZHAN Hongyan

doi:10.14009/j.issn.1672-2124.2023.02.010

您当前的位置：

首页 >

文章列表页 >

Efficacy of Xuanfei Tongluo Formula in the Treatment of Children with Mycoplasma Pneumoniae Pneumonia and Its Effects on Inflammatory Factors, sIgA, hBD2 and CAL

更新时间：2023-04-14

- Efficacy of Xuanfei Tongluo Formula in the Treatment of Children with Mycoplasma Pneumoniae Pneumonia and Its Effects on Inflammatory Factors, sIgA, hBD2 and CAL
- Issue 2, Pages: 178-181(2023)
- 作者机构：
  
  湖南中医药大学第二附属医院门诊儿科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2023.02.010
  CLC： R272
- Published：2023，
扫描看全文
DI Wenwen, LU Ying, ZHAN Hongyan. Efficacy of Xuanfei Tongluo Formula in the Treatment of Children with Mycoplasma Pneumoniae Pneumonia and Its Effects on Inflammatory Factors, sIgA, hBD2 and CAL. [J]. (2):178-181(2023)
DOI：

DI Wenwen, LU Ying, ZHAN Hongyan. Efficacy of Xuanfei Tongluo Formula in the Treatment of Children with Mycoplasma Pneumoniae Pneumonia and Its Effects on Inflammatory Factors, sIgA, hBD2 and CAL. [J]. (2):178-181(2023) DOI： 10.14009/j.issn.1672-2124.2023.02.010.

摘要

目的：探讨宣肺通络方治疗小儿肺炎支原体肺炎（MPP）的临床疗效。方法：选择2020年1月至2022年3月该院儿科收治的MPP患儿90例，按照随机数字表法分为治疗组和对照组，每组45例。对照组患儿予以西医常规治疗，包括吸氧、雾化吸入和补充液体等，并给予阿奇霉素序贯疗法；治疗组患儿在对照组治疗的基础上予以中药宣肺通络方口服，疗程均为2周。比较两组患儿治疗前后的中医证候评分，肺功能指标[第1秒最大呼气容积（FEV

）、呼气流量峰值（PEF）、用力肺活量（FVC）和FEV

/FVC]、血清烟酰胺磷酸核糖基转移酶（NAMPT）、人类软骨糖蛋白39（YKL-40）、白细胞介素8（IL-8）水平和唾液分泌型免疫球蛋白A（sIgA）、人β-防御素2（hBD2）及粪钙卫蛋白（CAL）含量，比较两组患儿治疗总有效率和不良反应发生率。结果：治疗后，治疗组患儿咳嗽、喘息、唇绀和发热评分均低于对照组（P＜0.01）

FEV

、PEF和FEV

/FVC水平高于对照组（P＜0.01）

血清NAMPT、YKL-40、IL-8水平低于对照组（P＜0.01）

唾液sIgA含量高于对照组（P＜0.01）

唾液hBD2、粪CAL含量低于对照组（P＜0.01）

差异均有统计学意义。治疗组患儿的总有效率为95.56%（43/45）

高于对照组的82.22%（37/45）

差异有统计学意义（P＜0.05）。治疗组患儿治疗期间的不良反应发生率为6.67%（3/45）

低于对照组的22.22%（10/45）

差异有统计学意义（P＜0.05）。结论：宣肺通络方可降低MPP患儿的中医证候评分，改善肺功能，提高气道免疫功能，抑制炎症因子表达，减少唾液内hBD2、粪CAL含量，治疗效果显著。

Abstract

OBJECTIVE: To probe into the clinical of Xuanfei Tongluo formula in the treatment of children with Mycoplasma pneumoniae pneumonia（MPP）. METHODS: A total of 90 children with MPP admitted into the department of pediatrics of the hospital from Jan. 2020 to Mar. 2022 were extracted to be divided into the treatment group and control group via the random number table method

with 45 cases in each group. The control group was treated with conventional western medicine

including oxygen inhalation

atomization inhalation

liquid supplement

and azithromycin sequential therapy. The treatment group received Xuanfei Tongluo formula on the basis of the control group

and the course of treatment was 2 weeks. Before and after treatment

the traditional Chinese medicine syndrome score

pulmonary function indicators [maximum expiratory volume at one second（FEV

）

peak expiratory flow（PEF）

forced vital capacity（FVC）

FEV

/FVC]

the contents of serum nicotinamide phosphoribosyltransferase（NAMPT）

human cartilage glycoprotein 39（YKL-40）

interleukin-8（IL-8）

salivary secretory immunoglobulin A（sIgA） and human β-defensin 2（hBD2） and fecal calprotectin（CAL） of two groups were compared. The total effective rate and incidence of adverse drug reactions were compared between two groups. RESULTS: After treatment

the scores of cough

wheezing

cyanosis and fever in the treatment group were lower than those in the control group（P

0.01）

FEV

PEF and FEV

/FVC were higher than those in the control group（P

0.01）

and the serum levels of NAMPT

YKL-40 and IL-8 were lower than those in the control group（P

0.01）

the salivary sIgA was significantly higher than that in the control group（P

0.01）

and the salivary hBD2 and fecal CAL were significantly lower than those in the control group（P

0.01）

with statistically significant differences. The total effective rate of the treatment group was 95.56%（43/45）

higher than 82.22%（37/45） of the control group

the difference was statistically significant（P

0.05）. The incidence of adverse drug reactions in the treatment group was 6.67%（3/45）

lower than 22.22%（10/45） in the control group

the difference was statistically significant（P

0.05）. CONCLUSIONS: Xuanfei Tongluo formula can reduce the traditional Chinese medicine syndrome score of children

improve lung function and airway immune function

inhibit the expression of inflammatory factors

reduce salivary hBD2 and fecal CAL

and has significant effects on MPP.

关键词

肺炎支原体肺炎中药宣肺通络方炎症因子

Keywords

Mycoplasma pneumoniae pneumoniaTraditional Chinese medicineXuanfei Tongluo formulaInflammatory factors

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Progress of Traditional Chinese Medicine in Promoting Wound Healing After Anal Fistula Surgery

Effects of Reduced Glutathione Infusion on Inflammatory Response in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Effects of Budesonide for Inhalation on Ventilator Weaning Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Analysis on 3401 Prescriptions of Traditional Chinese Medicine Decoction Pieces in the Treatment of Eczema

Efficacy of Modified Maxing Shigan Decoction in the Adjuvant Treatment of Mycoplasma Pneumonia in Children and its Effect on the Expression of Forkhead-Like Transcription Factors 3 and T Regulatory Cell

Related Author

WU Qiong

GAO Jihua

QI Wenyue

PEI Yan

DUAN Bingqian

LIU Ziyi

WANG Ran

ZHANG Xiangru

Related Institution

Dept.of Anus and Intestine, the First Affiliated Hospital of Hebei University of Chinese Medicine

Graduate School, Hebei University of Chinese Medicine

Dept.of Cardiology, the First Affiliated Hospital of Xi’an Jiaotong University

Dept.of Pharmacy, the First Affiliated Hospital of Xi’an Jiaotong University

Dept.of Respiratory,the First Affiliated Hospital,Xi’an Jiaotong University

⁰