OBJECTIVE: To probe into the efficacy and adverse drug reactions of compound Kushen injection in adjuvant treatment of moderate-severe chronic cancer pain of digestive system. METHODS: Totally 60 patients with moderate-severe chronic cancer pain of digestive system admitted into this hospital from Jan. 2019 to Jun. 2022 were divided into control group and treatment group via random number table. The control group（n=30） was treated with Oxycodone hydrochloride sustained release tablets alone

while the treatment group（n=30） was given compound Kushen injection based on the observation group. The efficacy

improvement of physical condition and incidence of adverse drug reactions were compared between two groups after treatment. RESULTS: After 3 days of treatment

the total effective rates of the control group and the treatment group were 70.00%（21/30） and 76.67%（23/30）

respectively; after 7 days of treatment

the total effective rates of the control group and the treatment group were 93.33%（28/30） and 96.67%（29/30）

respectively

the differences were not statistically significant（P>0.05）. After treatment

patients’ physical condition were significantly improved compared with that before treatment

but the improvement in the treatment group was more obvious

with statistically significant differences（P<0.05）. The incidences of constipation（66.67%

20/30）

dizziness and headache（23.33%

7/30）

nausea and vomiting（33.33%

10/30） in the treatment group were lower than those in the observation group（90.00%

27/30; 53.33%

16/30; 60.00%

18/30）

with statistically significant differences（P<0.05）. CONCLUSIONS: Compound Kushen injection combined with Oxycodone hydrochloride sustained release tablets can control moderate-severe chronic cancer pain of digestive system

improve patients’ physical condition and relieve adverse drug reactions.