OBJECTIVE: To investigate the rules of asarum in the prescription of traditional Chinese medicine decoction pieces in Wuhan Hospital of Integrated Traditional Chinese and Western Medicine（hereinafter referred to as “the hospital”）

so as to provide reference for the rational application of asarum in the treatment of skin diseases. METHODS: Outpatient traditional Chinese medicine decoction pieces prescriptions containing asarum diagnosed with skin diseases in the hospital in 2021 were extracted

and the prescription information was collected. Frequency analysis and association rule analysis were carried out for the application of asarum. RESULTS: A total of 1 004 traditional Chinese medicine decoction pieces prescriptions were included

mainly from the department of dermatology and traditional Chinese medicine. Asarum was mainly used in traditional Chinese medicine decoction

with the dosage from 2 to 15 g. There were 580 prescriptions（57.77%） with off-label use of traditional Chinese medicine. Frequency analysis results showed that the degree of off-label use in Asarum were 2 to 5 times

and no adverse drug reactions were found. The syndrome types with high frequency of asarum were diagnosed as cold-dampness syndrome

dampness-heat syndrome

and spleen deficiency and dampness excess syndrome. Association rule analysis results showed that the core drugs strongly associated with asarum were asarum

osmanthus twig and angelica sinensis

asarum

osmanthus twig and attached pieces. The core drug pair mainly included asarum and cinnamomum twig

angelica sinensis

poria cocos and licorice. CONCLUSIONS: Based on the analysis of prescription drugs

asarum often used in combination with cinnamon twig

angelica sinensis

poria cocos and licorice to increase efficiency and reduce toxicity

and there is a certain off-label use of asarum in the clinical treatment of skin diseases. The clinical application of asarum in the treatment of skin diseases provides data support for the reasonable compatibility and safe dose range of traditional Chinese medicine

which is conducive to promoting clinical safe drug use.