OBJECTIVE: To probe into the effects of Guijia Jiangu capsules on blood supply and healing of fracture end in elderly patients with intertrochanteric fracture of femur（IFOF） undergoing internal fixation. METHODS: A total of 136 elderly patients with IFOF admitted into this hospital from 2020 to 2021 were selected and divided into observation group（n=68） and control group（n=68） via random number table method. The control group was given proximal femoral nail anti-rotation（PFNA） for internal fixation

while the observation group was treated with Guijia Jiangu capsules based on the control group. The clinical efficacy and the recovery time

the hip joint function

serum hypoxia-inducible factor-1α（HIF-1α） and vascular endothelial growth factor（VEGF） before and after treatment

and incidences of postoperative complications were compared between two groups. RESULTS: The total effective rate of observation group was 94.12%（64/68）

which was higher than that of the control group（82.35%

56/68）

with statistically significant difference（P<0.05）. The detumescence time of affected limb and healing time of fracture were significantly shorter in the observation group than those in the control group

with statistically significant differences（P<0.05）. The Harris scores of the observation group at 2 months and 3 months after treatment were higher than those of the control group

with statistically significant differences（P<0.05）. The serum HIF-1α and VEGF levels of the observation group were higher than those of the control group

with statistically significant differences（P<0.05）. The incidence of postoperative complications of the observation group was 4.41%（3/68）

which was lower than that of the control group（14.71%

10/68）

with statistically significant difference（P<0.05）. CONCLUSIONS: The efficacy of Guijia Jiangu capsules on blood supply and healing of fracture end in elderly patients with IFOF undergoing internal fixation is remarkable

which can shorten the detumescence time of affected limb

promote the healing of fracture and the recovery of hip joint function

regulate serum HIF-1α and VEGF levels

and reduce postoperative complications.