Effects of Huangqi Guizhi Wuwu Decoction on Heart Rate Recovery from Bradyarrhythmia,Serum Fatty Acid Binding Protein Levels and Plasma Ang &#8545;,Adropin and Gal-3

ZHANG Chengcheng; WANG Na; WANG Qingkai

doi:10.14009/j.issn.1672-2124.2023.01.011

您当前的位置：

首页 >

文章列表页 >

Effects of Huangqi Guizhi Wuwu Decoction on Heart Rate Recovery from Bradyarrhythmia,Serum Fatty Acid Binding Protein Levels and Plasma Ang Ⅱ,Adropin and Gal-3

更新时间：2023-04-14

- Effects of Huangqi Guizhi Wuwu Decoction on Heart Rate Recovery from Bradyarrhythmia,Serum Fatty Acid Binding Protein Levels and Plasma Ang Ⅱ,Adropin and Gal-3
- Issue 1, Pages: 54-57(2023)
- 作者机构：
  
  河北省沧州中西医结合医院心血管内一科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2023.01.011
  CLC： R259
- Published：2023，
扫描看全文
ZHANG Chengcheng, WANG Na, WANG Qingkai. Effects of Huangqi Guizhi Wuwu Decoction on Heart Rate Recovery from Bradyarrhythmia,Serum Fatty Acid Binding Protein Levels and Plasma Ang Ⅱ,Adropin and Gal-3. [J]. (1):54-57(2023)
DOI：

ZHANG Chengcheng, WANG Na, WANG Qingkai. Effects of Huangqi Guizhi Wuwu Decoction on Heart Rate Recovery from Bradyarrhythmia,Serum Fatty Acid Binding Protein Levels and Plasma Ang Ⅱ,Adropin and Gal-3. [J]. (1):54-57(2023) DOI： 10.14009/j.issn.1672-2124.2023.01.011.

摘要

目的：探讨黄芪桂枝五物汤对缓慢性心律失常患者心率恢复、血清脂肪酸结合蛋白及血浆血管紧张素Ⅱ（AngⅡ）、Adropin、半乳糖凝集素（Gal）3的影响。方法：选择2020年4月至2021年4月该院收治的120例缓慢性心律失常患者，按随机数字表法分组，60例对照组患者给予常规治疗，60例观察组患者在对照组的基础上给予黄芪桂枝五物汤治疗。治疗前后检测两组患者的Gal-3、血管活性肠肽（VIP）、一氧化氮（NO）、AngⅡ、Adropin、生长分化因子（GDF）15、肌酸激酶同工酶（CK-MB）、心型脂肪酸结合蛋白（H-FABP）、内源性孤啡肽（N/OFQ）、左心室射血分数（LVEF）、心率、相邻NN间期差值的均方根（RMSSD）、每5 min NN间期平均值标准差（SDANN）及全部窦性心搏NN间期（SDNN）水平，比较两组患者的临床疗效。结果：治疗后，观察组患者的AngⅡ水平低于对照组，VIP、Adropin和NO水平高于对照组，Gal-3、GDF-15水平低于对照组，H-FABP、CK-MB和N/OFQ水平低于对照组，LVEF、心率水平高于对照组，RMSSD、SDANN水平低于对照组，SDNN水平高于对照组，差异均有统计学意义（P＜0.05）。观察组患者的总有效率为96.67%（58/60）

高于对照组的83.33%（50/60）

差异有统计学意义（P＜0.05）。结论：黄芪桂枝五物汤用于缓慢性心律失常患者的治疗，可改善其血管内皮功能，抑制机体炎症，减少心肌损伤，改善心率、心率变异性及心功能，提高临床疗效。

Abstract

OBJECTIVE: To probe into the effects of Huangqi Guizhi Wuwu decoction on heart rate recovery from bradyarrhythmia

serum fatty acid binding protein levels and plasma Ang Ⅱ

Adropin and galectin（Gal） 3. METHODS: A total of 120 patients with bradyarrhythmias admitted into the hospital from Apr. 2020 to Apr. 2021 were extracted to be divided into the control group and the observation group via the random number table method

with 60 cases in each group. The control group was treated with routine treatment

while the observation group received Huangqi Guizhi Wuwu decoction based on the control group. The levels of Gal-3

vasoactive intestinal peptide（VIP）

nitric oxide（NO） and Ang Ⅱ

Adropin

growth differentiation factor（GDF）-15

creatine kinase isoenzyme（CK-MB）

heart-type fatty acid binding protein（H-FABP）

endogenous nociceptin/orphanin FQ（N/OFQ）

left ventricular ejection fraction（LVEF）

heart rate（HR）

root mean square of the difference between successive NN intervals（RMSSD）

every 5 min NN standard deviation of mean interval（SDANN） and total NN interval（SDNN） before and after treatment in two groups were detected. Clinical efficacy of two groups were compared. RESULTS: After treatment

the level of Ang Ⅱ of the observation group was lower than that of the control group

the levels of VIP

Adropin and NO were higher than those of the control group

the levels of Gal-3

GDF-15 was lower than that of the control group

the levels of H-FABP

CK-MB and N/OFQ were lower than those of the control group

the levels of LVEF and HR were higher than those of the control group

the levels of RMSSD and SDANN were lower than those in the control group

the level of SDNN was higher than that of the control group

with statistically significant differences（P<0.05）. The total effective rate of the observation group was 96.67%（58/60）

higher than 83.33%（50/60） of the control group

the difference was statistically significant（P<0.05）. CONCLUSIONS: Huangqi Guizhi Wuwu decoction in the treatment of patients with bradyarrhythmias can improve vascular endothelial function

inhibit inflammation

reduce myocardial damage

improve heart rate

heart rate variability and cardiac function

and improve the clinical efficacy.

关键词

黄芪桂枝五物汤缓慢性心律失常血管内皮功能炎症心肌损伤心功能

Keywords

Huangqi Guizhi Wuwu decoctionBradyarrhythmiasVascular endothelial functionInflammationMyocardial injuryCardiac function

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Systematic Review on Efficacy and Safety of Huangqi Guizhi Wuwu Decoction Combined with Acupuncture in the Treatment of Diabetic Peripheral Neuropathy

Effects of Nicorandil Combined with Clopidogrel on Platelet Activation Indicators and Serum BNP and MMP-9 in Patients with Acute Coronary Syndrome After Percutaneous Coronary Intervention

Efficacy and Mechanism of Fuyuan Huoxue Decoction Combined with Percutaneous Vertebroplasty in the Treatment of Fresh Vertebral Compression Fractures

Efficacy of Photodynamic Therapy Combined with Minocycline Hydrochloride in the Treatment of Severe Periodontitis and Its Effects on miR-193a and MCP-1 Levels

Molecular Mechanism of Anti-Inflammatory Effects of Ruyi Jinhuang Powder Based on Network Pharmacology and Molecular Docking Technology

Related Author

QU Xinliang

ZHAO Bo

DUAN Guangjing

XIE Feng

DONG Taiwei

OU Li

WEI Peifeng

LI Min

Related Institution

College of Pharmacy, Shaanxi University of Chinese Medicine

Cardiac Rehabilitation Center, Beijing Rehabilitation Hospital, Capital Medical University

Dept.of Spine Surgery, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine

Dept.of Stomatology, South Campus of Fengfeng General Hospital of North China Medical Health Group

Dept.of Stomatology, North Campus of Fengfeng General Hospital of North China Medical Health Group

⁰

Effects of Huangqi Guizhi Wuwu Decoction on Heart Rate Recovery from Bradyarrhythmia,Serum Fatty Acid Binding Protein Levels and Plasma Ang Ⅱ,Adropin and Gal-3

DOI：10.14009/j.issn.1672-2124.2023.01.011

摘要

Abstract

关键词

Keywords

references