Effects of Modified Banxia Baizhu Tianma Decoction on CGRP, ET-1, Blood Viscosity and Cerebral Blood Flow Velocity in Patients with Posterior Circulation Ischemic Vertigo &#65288;Phlegm Stasis and Blocking Collaterals Type&#65289;

WANG Baoai; XU Yuting; WEI Huiyan; ZHANG Chunling; WANG Yu; FU Wenxiong; YIN Luoxi

doi:10.14009/j.issn.1672-2124.2023.01.010

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Effects of Modified Banxia Baizhu Tianma Decoction on CGRP, ET-1, Blood Viscosity and Cerebral Blood Flow Velocity in Patients with Posterior Circulation Ischemic Vertigo （Phlegm Stasis and Blocking Collaterals Type）

更新时间：2023-04-14

- Effects of Modified Banxia Baizhu Tianma Decoction on CGRP, ET-1, Blood Viscosity and Cerebral Blood Flow Velocity in Patients with Posterior Circulation Ischemic Vertigo （Phlegm Stasis and Blocking Collaterals Type）
- Issue 1, Pages: 49-53(2023)
- 作者机构：
  
  海口市中医医院脑病科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2023.01.010
  CLC： R277.7
- Published：2023，
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WANG Baoai, XU Yuting, WEI Huiyan, et al. Effects of Modified Banxia Baizhu Tianma Decoction on CGRP, ET-1, Blood Viscosity and Cerebral Blood Flow Velocity in Patients with Posterior Circulation Ischemic Vertigo （Phlegm Stasis and Blocking Collaterals Type）. [J]. (1):49-53(2023)
DOI：

WANG Baoai, XU Yuting, WEI Huiyan, et al. Effects of Modified Banxia Baizhu Tianma Decoction on CGRP, ET-1, Blood Viscosity and Cerebral Blood Flow Velocity in Patients with Posterior Circulation Ischemic Vertigo （Phlegm Stasis and Blocking Collaterals Type）. [J]. (1):49-53(2023) DOI： 10.14009/j.issn.1672-2124.2023.01.010.

摘要

目的：探讨加味半夏白术天麻汤对后循环缺血性眩晕（痰瘀阻络型）患者降钙素基因相关肽（CGRP）、内皮素1（ET-1）、血液黏度及脑血流速度的影响。方法：纳入2018年5月至2021年6月于该院就诊的126例后循环缺血性眩晕（痰瘀阻络型）患者，根据随机数字表法分为观察组和对照组，每组63例。对照组患者采用西医常规治疗，观察组患者在对照组的基础上联合加味半夏白术天麻汤治疗。治疗4周后比较疗效；观察两组患者治疗前后CGRP、超氧化物歧化酶（SOD）和ET-1水平变化，血液流变学状态改善情况，脑血流速度[椎基底动脉（BA）、左椎动脉（LVA）和右椎动脉（RVA）]改善情况，眩晕障碍量表（DHI）、健康状况调查简表（SF-36）和Berg平衡量表（BBS）评分。结果：治疗后，观察组患者血清CGRP、SOD水平较对照组更高，ET-1水平更低，差异均有统计学意义（P＜0.05）。治疗后，观察组患者血浆黏度、全血低切黏度和全血高切黏度较对照组更低，差异均有统计学意义（P＜0.05）。治疗后观察组患者脑血流速度（BA、LVA和RVA）较对照组更快，差异均有统计学意义（P＜0.05）。治疗后，观察组患者的DHI评分较对照组更低，SF-36、BBS评分较对照组更高，差异均有统计学意义（P＜0.05）。观察组患者的总有效率为95.24%（60/63）

高于对照组的77.78%（49/63）

差异有统计学意义（P＜0.05）。结论：后循环缺血性眩晕（痰瘀阻络型）患者在西医常规治疗的基础上联合加味半夏白术天麻汤治疗的效果显著，可调节血管内皮功能，调节血流动力学，促进脑部血供恢复，提高临床疗效。

Abstract

OBJECTIVE: To probe into the effects of modified Banxia Baizhu Tianma decoction on calcitonin gene-related peptide（CGRP）

endothelin-1（ET-1）

blood viscosity and cerebral blood flow velocity in patients with posterior circulation ischemic vertigo（phlegm stasis and blocking collaterals type）. METHODS: Totally 126 patients with posterior circulation ischemic vertigo（phlegm stasis and blocking collaterals type） admitted into the hospital from May 2018 to Jun. 2021 were extracted to be divided into the observation group and the control group via the random number table

with 63 cases in each group. The control group received conventional western medicine treatment

while the observation group was treated with modified Banxia Baizhu Tianma decoction based on the control group. After 4 weeks of treatment

the clinical efficacy was compared. Changes of CGRP

superoxide dismutase（SOD） and ET-1 levels

improvement of hemorheology

and improvement of cerebral blood flow velocity [vertebrobasilar artery（BA）

left vertebral artery（LVA） and right vertebral artery（RVA）] before and after treatment were observed in two groups. The scores of Dizziness Handicap Inventory（DHI）

36-item Short Form Health Survey（SF-36） and Berg Balance Scale（BBS） were recorded. RESULTS: After treatment

the serum CGRP and SOD levels were higher

the ET-1 level was lower in the observation group than those in the control group

with statistically significant differences（P<0.05）. After treatment

the plasma viscosity

whole blood low shear viscosity and whole blood high shear viscosity of the observation group were lower than those of the control group

with statistically significant differences（P<0.05）. The cerebral blood flow velocity（BA

LVA and RVA） of the observation group were faster than those of the control group after treatment

with statistically significant differences（P<0.05）. After treatment

the DHI score was lower

the SF-36 and BBS scores were higher in the observation group than those in the control group

with statistically significant differences（P<0.05）. The total effective rate of observation group was 95.24%（60/63）

which was higher than that of the control group（77.78%

49/63）

with statistically significant difference（P<0.05）. CONCLUSIONS: The efficacy of conventional western medicine combined with modified Banxia Baizhu Tianma decoction in the treatment of patients with posterior circulation ischemic vertigo（phlegm stagnation and blocking collaterals type） is remarkable

which can regulate vascular endothelial function and hemodynamics

promote the recovery of cerebral blood supply

improve clinical efficacy.

关键词

加味半夏白术天麻汤后循环缺血性眩晕痰瘀阻络型血管内皮功能血液黏度脑血流速度生活质量

Keywords

Modified Banxia Baizhu Tianma decoctionPosterior circulation ischemic vertigoPhlegm stasis and blocking collaterals typeVascular endothelial functionBlood viscosityCerebral blood flow velocityQuality of life

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Effects of Modified Banxia Baizhu Tianma Decoction on CGRP, ET-1, Blood Viscosity and Cerebral Blood Flow Velocity in Patients with Posterior Circulation Ischemic Vertigo （Phlegm Stasis and Blocking Collaterals Type）

DOI：10.14009/j.issn.1672-2124.2023.01.010

摘要

Abstract

关键词

Keywords

references