Comparative Study on Different Administration Method of Propofol in Breast Cancer Surgery

ZHOU Caishan; CAI Qinfeng; WU Jiaying; GAN Zuren

doi:10.14009/j.issn.1672-2124.2022.12.010

您当前的位置：

首页 >

文章列表页 >

Comparative Study on Different Administration Method of Propofol in Breast Cancer Surgery

更新时间：2023-04-16

- Comparative Study on Different Administration Method of Propofol in Breast Cancer Surgery
- Issue 12, Pages: 1472-1475(2022)
- 作者机构：
  
  海口市中医医院麻醉科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.12.010
  CLC： R614;R737.9
- Published：2022，
扫描看全文
ZHOU Caishan, CAI Qinfeng, WU Jiaying, et al. Comparative Study on Different Administration Method of Propofol in Breast Cancer Surgery. [J]. (12):1472-1475(2022)
DOI：

ZHOU Caishan, CAI Qinfeng, WU Jiaying, et al. Comparative Study on Different Administration Method of Propofol in Breast Cancer Surgery. [J]. (12):1472-1475(2022) DOI： 10.14009/j.issn.1672-2124.2022.12.010.

摘要

目的：探讨丙泊酚不同给药方式对乳腺癌手术患者循环功能、脑功能状态指数（CSI）及Th17/Treg水平的影响。方法：前瞻性选取2019年6月至2021年6月该院收治的拟行乳腺癌手术的患者130例，根据随机数字表法分为A组和B组，各65例。两组患者均应用丙泊酚，A组患者采用闭环靶控输注（CLTCI）

B组患者采用开环靶控输注（OLTCI）。观察两组患者麻醉诱导前（T

）、插管即刻（T

）、拔管即刻（T

）和拔管后（T

）时的循环功能[平均动脉压（MAP）、心率（HR）、呼吸频率（RR）及呼气末二氧化碳(P

)]和CSI

手术前后Th17/Treg水平，丙泊酚总用量、苏醒时间、拔管时间、拔管后疼痛程度和不良事件发生情况。结果：（1）T

、T

和T

时，A组患者的MAP、HR和RR高于B组，CSI、P

低于B组，且波动幅度小于B组，差异均有统计学意义（P＜0.05）;（2）术后24 h、72 h时，A组患者的Th17水平高于B组，Treg水平低于B组，差异均有统计学意义（P＜0.05）;（3）A组患者丙泊酚总用量少于B组，苏醒时间及拔管时间短于B组，差异均有统计学意义（P＜0.05）;（4）A、B组患者不良反应事件发生率比较[3.08%（2/65）vs. 7.69%（5/65）]

差异无统计学意义（P＞0.05）。结论：丙泊酚CLTCI在循环功能、CSI、Th17/Treg水平方面的效果优于丙泊酚OLTCI

可作为乳腺癌手术患者围手术期麻醉管理方案之一。

Abstract

OBJECTIVE: To probe into the effects of different administration methods of propofol on circulatory function

cerebral state index（CSI） and Th17/Treg level in patients undergoing breast cancer surgery. METHODS: A total of 130 patients undergoing breast cancer surgery in this hospital from Jun. 2019 to Jun. 2021 were prospectively selected and divided into groups A and group B via random number table

with 65 cases in each group. Both groups were given propofol

group A was administrated by closed-loop target-controlled infusion（CLTCI）

and group B was administrated open-loop target-controlled infusion（OLTCI）. The circulatory function [mean arterial pressure（MAP）

heart rate（HR）

respiratory rate（RR）

end-tidal carbon dioxide(P

)]

CSI value

postoperative Th17/Treg level

total dosage of propofol

wake-up time

extubation time

pain degree after extubation and incidence of adverse events in the two groups were observed before anesthesia induction（T

）

immediately after intubation（T

）

immediately after extubation（T

） and after extubation. RESULTS:（1） At T

and T

the MAP

HR and RR of group A were higher than those of group B

the CSI value and P

of group A were lower than those of group B

and the fluctuation range was smaller than that of group B

with statistically significant differences（P

0.05）;（2） at 24 h and 72 h after surgery

the Th17 level of group A was higher than that of group B

the Treg level of group A was lower than that of group B

with statistically significant differences（P

0.05）;（3） the total dosage of propofol in group A was less than that of group B

the wake-up time and extubation time of group A were shorter than group B

with statistically significant differences（P

0.05）;（4） the difference in the incidences of adverse events between group A and group B [3.08%（2/65） vs. 7.69%（5/65）] was not statistically significant（P

0.05）. CONCLUSIONS: Propofol administrated by CLTCI is better than administrated by LTCI in terms of circulatory function

CSI and Th17/Treg levels

which can be used as one of the perioperative anesthesia management programs for breast cancer patients.

关键词

乳腺癌手术丙泊酚闭环靶控输注循环功能脑功能状态指数Th17/Treg

Keywords

Breast cancerSurgeryPropofolClosed-loop target-controlled infusionCirculatory functionCerebral state indexTh17/Treg

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of Continuous Intravenous Infusion of Dexmedetomidine Combined with Oxycodone on Inflammatory Response and Immune Function in Patients with Breast Cancer During General Anesthesia

Effects of Danshen Ligustrazine Injection Combined with EC-T Regimen on Short-Term Efficacy, Immune Function and Quality of Life in Patients with Breast Cancer After Surgery

Inhibition of Propofol on Migration and Invasion of Cervical Cancer Cells Through miR-802/PTCH1/SHH Pathway

Molecular Mechanism of Iphigenia Indica in the Treatment of Breast Cancer Based on Network Pharmacology

Effects of Apatinib on Tumor Inhibition Rate and Tumor Cell Apoptosis in Breast Cancer Mouse Model by Regulating Extracellular Regulated Kinase 1/2 Pathway

Related Author

LIU Xiaomei

NING Lijuan

LI Yanli

GAO Yang

ZHANG Yiwen

LIU Yinfeng

ZHANG Jing

ZHANG Kexian

Related Institution

Dept.of Anesthesiology,Sixth Medical Center of Chinese PLA General Hospital

Dept. of General Surgery, Qinhuangdao the First Hospital

Dept. of Breast Surgery, Zhejiang Cancer Hospital

Dept. of Breast Surgery, Qinhuangdao the First Hospital

Dept. of Critical Care Medicine, Qinhuangdao the First Hospital

⁰