OBJECTIVE: To probe into the effects of modified Chaihu Shugan powder combined with acupoint application on sleep and emotions in patients with sleep disorder of liver-depression and qi-stagnation. METHODS: A total of 100 patients with sleep disorder of liver-depression and qi-stagnation admitted into Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from Jun. 2020 to Jun. 2021 were selected and randomly divided into control group（dexzopiclone tablets） and observation group（modified Chaihu Shugan powder combined with acupoint application）

with 50 cases in each group and observed for 3 months. Scores of Self Rating Scale of Sleep（SRSS）

Pittsburgh Sleep Quality Index（PSQI）

polysomnogram

Hamilton Anxiety Scale（HAMA） and Hamilton Depression Scale（HAMD） were compared between two groups

and the correlation were analyzed. RESULTS: The total effective rate of the observation group was 90.0%（45/50）

which was significantly higher than that of the control group（74.0%

37/50）

with statistically significant difference（P<0.05）. The PSQI score of the observation group after 2 weeks of treatment were significantly lower than that of the control group（P<0.01）

the SRSS score of the observation group after 4 weeks of treatment were significantly lower than that of the control group（P<0.05）

with statistically significant differences. Compared with the control group

the total sleep time

REM sleep latency

N2 and N3 stage sleep times of the observation group were significantly prolonged

the proportion and efficiency of N3 stage sleep were significantly increased; the sleep latency and wake time of the observation group were significantly shortened

the proportions of N1 and N2 stage sleep were significantly decreased

with statistically significant differences（P<0.05）. The HAMD and HAMA scores were significantly negatively correlated with the total sleep time and N3 stage sleep

and significantly positively correlated with PSQI score. CONCLUSIONS: The combination of modified Chaihu Shugan powder with acupoint application has better overall improvement on subjective sleep quality

objective sleep structure and sleep process in patients with sleep disorder of liver-depression and qi-stagnation

and can alleviate patients’ anxiety and depression

improve their sleep quality. Sleep disorders are correlated with patients’ anxiety and depression status.