OBJECTIVE: To probe into the treatment effects of bronchoscopic lavage complicated with azithromycin in the treatment of children with lobar pneumonia. METHODS: Totally 200 children with lobar pneumonia admitted into the hospital in 2021 were extracted to be divided into the control group and the observation group via the lottery method

with 100 cases in each group. Both groups received routine treatment after admission

on this basis

the control group was treated with orally azithromycin for 2 weeks; and the observation group was given bronchoscopic lavage on the basis of the control group

from twice to 3 times according to the condition of the children. The improvement time of clinical symptoms in two groups was observed. The levels of inflammatory indicators [C-reactive protein（CRP）

procalcitonin（PCT）

interleukin 6（IL-6） and high mobility group protein B1（HMGB1）]

blood gas indicators [partial pressure of arterial oxygen（PaO

2

）

partial pressure of arterial carbon dioxide（PaCO

2

） and pH] before treatment and after treatment of 2 weeks were compared between two groups. The occurrence of adverse drug reactions was recorded in both groups. RESULTS: Compared with the control group

the improvement time of clinical symptoms of children in the observation group was shorter

with statistically significant difference（P

<

0.05）. After treatment of 2 weeks

the levels of serum CRP

PCT

IL-6 and HMGB1 in both groups decreased significantly

and the observation group was even lower

with statistically significant differences（P

<

0.05）. After treatment of 2 weeks

the PaO

2

and pH values of both groups increased significantly

and the observation group was even higher

while PaCO

2

in both groups decreased significantly

and the observation group was even lower

with statistically significant differences（P

<

0.05）. There was no significant difference in the incidence of anorexia

dizziness

nausea

drowsiness

hoarseness and nasal mucosal bleeding between the observation group and the control group during treatment（P

>

0.05）. CONCLUSIONS: Bronchoscopic lavage complicated with azithromycin in the treatment of lobar pneumonia can promote the improvement of clinical symptoms

reduce the inflammatory response and improve the blood gas indicators of children

with mild adverse drug reactions.