OBJECTIVE: To probe into the effects of asiaticoside（AS） on cognitive function

inflammatory response

oxidative stress and silent information regulator 1（SIRT1）/endoplasmic reticulum stress（ER stress） pathway protein in mice with epileptic（EP）. METHODS: EP mouse model were established

so that the successfully modeled EP mice were randomly divided into model group

AS low dose group（20 mg/kg AS）

AS medium dose group（40 mg/kg AS）

AS high dose group（80 mg/kg AS） and positive control group（0.2 g/kg sodium valproate）

with 10 mice in each group; and another 10 healthy mice were taken as the control group. Except for the mice in the model group and the control group were given distilled water by gavage

the mice in other groups were given corresponding doses for drug intervention

once a day for two weeks. After administration

the frequency and total duration of status epilepticus（SE） of EP mice were observed; The Morris water maze test was performed to measure the cognitive function of mice; the enzyme-linked immunosorbent assay was used to determine the interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） levels in serum

superoxide dismutase（SOD） and malondialdehyde（MDA） levels in brain tissue; the Western blot was adopted to detect the expression of SIRT1 and ER stress-related proteins in brain tissue [transcription factor C/EBP homologous protein（CHOP）

immunoglobulin heavy chain binding protein（BIP）

protein kinase R-like endoplasmic reticulum kinase（PERK）

phosphorylated PERK（p-PERK）

eukaryotic translation initiation factor-2α（eIF2α） and phosphorylated eIF2α（p-eIF2α）]. RESULTS: Compared with the control group

the frequency of SE was increased

the total duration and escape latency of SE were prolonged

the IL-6 and TNF-α levels in serum

the MDA

CHOP

BIP

p-PERK/PERK and p-eIF2α/eIF2α protein expression levels in brain tissue were increased

the number of times to swim across platform position was decreased

the SOD and SIRT1 protein expression levels in brain tissue were decreased in the model group

with statistically significant differences（P<0.05）. Compared with the model group

the frequency of SE was decreased

the total duration and escape latency of SE were shortened

the IL-6 and TNF-α levels in serum

the MDA

CHOP

BIP

p-PERK/PERK and p-eIF2α/eIF2α protein expression levels in brain tissue were decreased

the number of times to swim across platform position was increased

the SOD and SIRT1 protein expression levels in brain tissue were increased in the AS low

medium and high dose groups and the positive control group

with statistically significant differences（P<0.05）

there were dose-dependent in the AS low

medium and high dose groups（P<0.05）; there was no statistical significance in differences in the above indicators between the AS high dose group and the positive control group（P>0.05）. CONCLUSIONS: AS can improve cognitive function

relieve inflammatory response and oxidative stress in EP mice

which may be related to activating the expression of SIRT1 protein and alleviating ER stress.