Progress of Therapeutic Drug Monitoring of Biologic Agents for Rheumatic and Immunological Diseases

XIONG Xiaofu; TIAN Xueke; QIN Zhiying; YANG Jing; ZHANG Xiaojian

doi:10.14009/j.issn.1672-2124.2022.11.028

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Progress of Therapeutic Drug Monitoring of Biologic Agents for Rheumatic and Immunological Diseases

更新时间：2023-04-16

- Progress of Therapeutic Drug Monitoring of Biologic Agents for Rheumatic and Immunological Diseases
- Issue 11, Pages: 1404-1408(2022)
- 作者机构：
  
  1. 郑州大学第一附属医院药学部
  2. 河南省精准临床药学重点实验室
  3. 河南省精准临床药学应用与转化工程研究中心
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.11.028
  CLC： R969.1
- Published：2022，
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XIONG Xiaofu, TIAN Xueke, QIN Zhiying, et al. Progress of Therapeutic Drug Monitoring of Biologic Agents for Rheumatic and Immunological Diseases. [J]. (11):1404-1408(2022)
DOI：

XIONG Xiaofu, TIAN Xueke, QIN Zhiying, et al. Progress of Therapeutic Drug Monitoring of Biologic Agents for Rheumatic and Immunological Diseases. [J]. (11):1404-1408(2022) DOI： 10.14009/j.issn.1672-2124.2022.11.028.

摘要

生物制剂在风湿免疫病中应用广泛，表现出非线性药动学特征，且血药浓度在个体内和个体间呈较高的变异。治疗药物监测（TDM）可通过检测生物制剂的血药浓度和抗药物抗体指导用药方案的制定和调整，但因缺少指导性文件尚未常规开展TDM。本文从风湿免疫病治疗领域生物制剂的现状、药动学特点、TDM的常用生物分析方法及生物制剂开展TDM的临床研究等方面概述最新的研究进展，以期为生物制剂的个体化用药提供参考和借鉴。

Abstract

The biologic agent is widely used for rheumatic and immunological diseases

which presents non-linear pharmacokinetic characteristics

and have high intra-and inter-individual variability in blood concentrations. Therapeutic drug monitoring（TDM） can guide the formulation and adjustment of medication regimen by detecting the blood concentration and anti-drug antibody

but TDM has not been routinely carried out due to the lack of guidance documents. This paper summarizes the latest research progress of the current status of biologic agents

pharmacokinetic characteristics

main bioanalytical methods for TDM and clinical studies on TDM of biologic agents in the field of rheumatic and immunological diseases

hoping to provide reference for the individualized medication of biologic agents.

关键词

生物制剂风湿免疫病治疗药物监测

Keywords

Biologic agentsRheumatic and immunological diseasesTherapeutic drug monitoring

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