Comparative Analysis on Adverse Drug Reactions of Domestic and Imported Iodixanol Injection

TIAN Lei; HUANG Lei; YU Li; QIU Zhaojuan

doi:10.14009/j.issn.1672-2124.2022.11.026

您当前的位置：

首页 >

文章列表页 >

Comparative Analysis on Adverse Drug Reactions of Domestic and Imported Iodixanol Injection

更新时间：2023-04-16

- Comparative Analysis on Adverse Drug Reactions of Domestic and Imported Iodixanol Injection
- Issue 11, Pages: 1397-1399(2022)
- 作者机构：
  
  江苏省中医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.11.026
  CLC： R981
- Published：2022，
扫描看全文
TIAN Lei, HUANG Lei, YU Li, et al. Comparative Analysis on Adverse Drug Reactions of Domestic and Imported Iodixanol Injection. [J]. (11):1397-1399(2022)
DOI：

TIAN Lei, HUANG Lei, YU Li, et al. Comparative Analysis on Adverse Drug Reactions of Domestic and Imported Iodixanol Injection. [J]. (11):1397-1399(2022) DOI： 10.14009/j.issn.1672-2124.2022.11.026.

摘要

目的：比较分析国产与进口碘克沙醇注射液在临床使用中发生的药品不良反应（ADR）

为临床合理用药提供数据支持。方法：统计2020—2021年该院所有使用碘克沙醇注射液的患者，根据所使用碘克沙醇注射液的生产企业分为三组（2个国产碘克沙醇注射液组、1个进口碘克沙醇注射液组）

收集发生ADR的患者基本情况，以及ADR的严重程度、发生时间和临床表现等信息。结果：纳入29 335例使用碘克沙醇注射液的患者，共发生116例ADR

ADR发生率为0.40%。三组使用碘克沙醇注射液患者的ADR发生率比较，差异无统计学意义（P＞0.05）;三组患者的男女比例、平均年龄和基础疾病占比比较，差异均无统计学意义（P＞0.05）;三组患者的ADR严重程度、发生时间和临床表现比较，差异均无统计学意义（P＞0.05）。结论：2种国产碘克沙醇注射液与进口碘克沙醇注射液的ADR发生率均较低，且多不严重，在临床使用安全性方面具有可比性。

Abstract

OBJECTIVE: To compare and analyze the adverse drug reactions（ADR） of domestic and imported iodixanol injection during clinical application

so as to provide data support for clinical rational application. METHODS: All the patients treated with iodixanol injection in the hospital from 2020 to 2021 were analyzed

which were divided into three groups according to the manufacturer of iodixanol injection（two groups of domestic iodixanol injection and one group of imported iodixanol injection）

the general information of patients with ADR

as well as the severity

occurrence time and clinical manifestations of ADR were collected. RESULTS: Totally 29 335 patients treated with iodixanol injection were enrolled

and 116 cases of ADR occurred

with the incidence rate of 0.40%. There was no statistical significance in difference in the incidence of ADR among the three groups（P>0.05）; there were no statistical significance in differences in the male-female ratio

average age and proportion of basic diseases among the three groups（P>0.05）; there was no statistical significance in differences in the severity

occurrence time and clinical manifestations of ADR（P>0.05）. CONCLUSIONS: The two kinds of domestic iodixanol injection and imported iodixanol injection had the lower incidence of ADR

and the ADR were non-severe

which is comparable in terms of clinical use safety.

关键词

碘克沙醇药品不良反应比较分析

Keywords

IodixanolAdverse drug reactionsComparative analysis

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of Literature on Case Reports of Adverse Drug Reactions Induced by Montelukast Sodium in Children

Comparative Analysis on Adverse Drug Reactions Between Ibuprofen and Acetaminophen

Domestic and Foreign Literature of Adverse Drug Reactions Induced by Tigecycline

Literature Analysis of Hemophagocytic Lymphohistiocytosis Induced by Antiepileptic Drugs

Meta-Analysis and Safety Evaluation on Clinical Efficacy of Lorlatinib in the Treatment of Non-Small Cell Lung Cancer

Related Author

LIU Xiaohui

YU Boran

TIAN Chao

CHENG Haixin

ZHAO Libo

WANG Xiaoling

GU Tongtong

ZHANG Hang

Related Institution

Dept.of Pharmacy, Children’s Hospital, Capital Institute of Pediatrics

Dept.of Pharmacy, Beijing Children’s Hospital, Capital Medical University,National Center for Children’s Health

Institution of National Drug Clinical Trails, the Affiliated Hospital of Xuzhou Medical University

School of Pharmacy, Nanjing Medical University

Dept.of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

⁰