Systematic Review of Runzao Zhiyang Capsules Combined with Antihistamine in the Treatment of Chronic Urticaria

YANG Ruifeng; HUANG Yuxin; QI Xiangjun; MO Jiahao; CHEN Qiqi; HOU Jingxuan; CHEN Daman; LIU Bin; CHEN Huicong; LIN Ying

doi:10.14009/j.issn.1672-2124.2022.11.020

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Systematic Review of Runzao Zhiyang Capsules Combined with Antihistamine in the Treatment of Chronic Urticaria

更新时间：2023-04-16

- Systematic Review of Runzao Zhiyang Capsules Combined with Antihistamine in the Treatment of Chronic Urticaria
- Issue 11, Pages: 1368-1374(2022)
- 作者机构：
  
  1. 北京中医药大学中医学院
  2. 广州中医药大学第五临床医学院
  3. 广州中医药大学第一临床医学院
  4. 广州中医药大学第二临床医学院
  5. 黑龙江中医药大学人文与管理学院
  6. 广州中医药大学第四临床医学院
  7. 广东省中医院大学城医院皮肤科
  8. 广东省中医药防治难治性慢病重点实验室
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.11.020
  CLC： R758.24
- Published：2022，
扫描看全文
YANG Ruifeng, HUANG Yuxin, QI Xiangjun, et al. Systematic Review of Runzao Zhiyang Capsules Combined with Antihistamine in the Treatment of Chronic Urticaria. [J]. (11):1368-1374(2022)
DOI：

YANG Ruifeng, HUANG Yuxin, QI Xiangjun, et al. Systematic Review of Runzao Zhiyang Capsules Combined with Antihistamine in the Treatment of Chronic Urticaria. [J]. (11):1368-1374(2022) DOI： 10.14009/j.issn.1672-2124.2022.11.020.

摘要

目的：系统评价润燥止痒胶囊联合抗组胺药治疗慢性荨麻疹（CU）的疗效及安全性。方法：检索PubMed、the Cochrane Library、Embase、Web of science、中国知网、中国生物医学文献数据库、万方数据库和维普数据库共8个数据库，并手动检索纳入文献的参考文献等进行补充检索，收集润燥止痒胶囊联合抗组胺药对比单纯使用抗组胺药治疗CU的随机对照试验，检索时限为建库至2021年6月。由2名研究人员独立完成筛选文献、提取资料和评价纳入研究的质量后，采用RevMan 5.3软件进行Meta分析，并采用Stata 15.1软件检验发表偏倚。结果：共纳入32项研究，合计3 061例CU患者。Meta分析结果表明，润燥止痒胶囊联合抗组胺药的总有效率优于单纯使用抗组胺药（RR=1.16

95%CI=1.13～1.19

P＜0.000 01）

不良反应发生率低于单纯使用抗组胺药（RR=0.49

95%CI=0.40～0.61

P＜0.000 01）

复发率低于单纯使用抗组胺药（RR=0.42

95%CI=0.31～0.57

P＜0.000 01）

差异均有统计学意义，但证据质量有待提高。发表偏倚检验及非参数剪补法分析结果显示，总有效率结局指标存在偏倚，但可能存在的发表偏倚未对结果造成影响。结论：基于现有证据，对比单纯使用抗组胺药，润燥止痒胶囊联合抗组胺药治疗CU的疗效肯定，不良反应发生率和复发率较低。但由于纳入研究的质量较低，存在较高偏倚风险，仍需谨慎看待上述结果。

Abstract

OBJECTIVE: To systematically evaluate the efficacy and safety of Runzao Zhiyang capsules combined with antihistamine in the treatment of chronic urticaria（CU）. METHODS: PubMed

the Cochrane Library

Embase

Web of Science

CNKI

CBM

Wanfang Data and VIP database were retrieved to collect the randomized controlled trial of Runzao Zhiyang capsules combined with antihistamine versus antihistamine alone in the treatment of CU

and the included references were manually searched for supplementary retrieval. The retrieval time was from the establishment of the database to Jun. 2021. Two researchers independently screened the literature

extracted data and evaluated the quality of the included studies. Meta-analysis was performed by using RevMan 5.3 software

and publication bias was tested by Stata 15.1 software. RESULTS: A total of 32 studies were enrolled

including 3 061 patients with CU. Meta-analysis showed that the total effective rate of Runzao Zhiyang capsules combined with antihistamine was better than that of antihistamine alone（RR=1.16

95%CI=1.13-1.19

P<0.000 01）

and the incidence of adverse drug reactions was lower than that of antihistamine alone（RR=0.49

95%CI=0.40-0.61

P<0.000 01）

the recurrence rate was lower than that of antihistamine alone（RR=0.42

95%CI=0.31-0.57

P<0.000 01）

the differences were statistically significant

yet the evidence quality remained to be improved. Results of publication bias test and non-parametric shear and supplement method showed that the outcome index of total effective rate was biased

but the possible publication bias did not affect the results. CONCLUSIONS: Based on the existing evidence

compared with antihistamine alone

Runzao Zhiyang capsules combined with antihistamine has significant effect in the treatment of CU

with a lower incidence of adverse drug reactions and recurrence. However

due to the low quality of the included studies and the high risk of bias

the above results need to be viewed with caution.

关键词

润燥止痒胶囊抗组胺药慢性荨麻疹Meta分析

Keywords

Runzao Zhiyang capsulesAntihistamineChronic urticariaMeta-analysis

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