Pharmacoeconomic Evaluation of Xianyu Capsules in the Treatment of Epilepsy Based on Decision Tree Model

LEI Chao; CUI Xin; WANG Zhifei; XIE Yanming

doi:10.14009/j.issn.1672-2124.2022.11.019

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Pharmacoeconomic Evaluation of Xianyu Capsules in the Treatment of Epilepsy Based on Decision Tree Model

更新时间：2023-04-16

- Pharmacoeconomic Evaluation of Xianyu Capsules in the Treatment of Epilepsy Based on Decision Tree Model
- Issue 11, Pages: 1365-1367(2022)
- 作者机构：
  
  中国中医科学院中医临床基础医学研究所
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.11.019
  CLC： R956;R742.1
- Published：2022，
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LEI Chao, CUI Xin, WANG Zhifei, et al. Pharmacoeconomic Evaluation of Xianyu Capsules in the Treatment of Epilepsy Based on Decision Tree Model. [J]. (11):1365-1367(2022)
DOI：

LEI Chao, CUI Xin, WANG Zhifei, et al. Pharmacoeconomic Evaluation of Xianyu Capsules in the Treatment of Epilepsy Based on Decision Tree Model. [J]. (11):1365-1367(2022) DOI： 10.14009/j.issn.1672-2124.2022.11.019.

摘要

目的：评估痫愈胶囊治疗癫痫的经济性。方法：基于1篇已发表的随机对照试验，从卫生体系角度出发，构建痫愈胶囊联合丙戊酸镁缓释片治疗癫痫的决策树模型，以治疗前后癫痫发作次数减少率为效果指标，以药品成本和疾病治疗的年度门诊诊疗费用计算成本参数，评价痫愈胶囊联合丙戊酸镁缓释片相比单独使用丙戊酸镁缓释片在癫痫患者中的经济性，并采用敏感性分析对结果的稳健性进行验证。结果：成本-效果分析结果显示，患者用药治疗60 d后，痫愈胶囊联合丙戊酸镁缓释片治疗方案能够明显减少仅使用丙戊酸镁缓释片治疗期间的癫痫发作次数；痫愈胶囊联合丙戊酸镁缓释片治疗方案的治疗成本高于仅使用丙戊酸镁缓释片，效果产出也高于仅使用丙戊酸镁缓释片，增量成本-效果比为7 051.79元，约为2020年我国人均可支配收入的0.22倍；敏感性分析结果表明，本研究结果相对稳健。结论：本研究中患者的意愿支付阈值为2020年我国人均可支配收入，在该假设下采用痫愈胶囊联合丙戊酸镁缓释片治疗比单独使用丙戊酸镁缓释片治疗更具有经济性。开展痫愈胶囊治疗癫痫的经济学评价，有利于合理配置医疗资源，便于医师和患者合理使用药物。

Abstract

OBJECTIVE: To evaluate the economy of Xianyu capsules in the treatment of epilepsy. METHODS: Based on a published randomized controlled trial

the decision tree model of treating epilepsy with Xianyu capsules combined with Magnesium valproate sustained-release tablets was constructed from the perspective of health system. The reduction rate of epilepsy before and after treatment was taken as the effect index

and the cost parameters were calculated based on the drug cost and the annual outpatient treatment cost of disease treatment. The economy of Xianyu capsules combined with Magnesium valproate sustained-release tablets compared with magnesium valproate sustained-release tablets alone in the treatment of patients with epilepsy was evaluated. Sensitivity analysis was used to verify the robustness of the results. RESULTS: The cost-effectiveness analysis showed that after 60 d of treatment

the treatment regimen of Xianyu capsules combined with Magnesium valproate sustained-release tablets could significantly reduce the number of epilepsy. The treatment cost of Xianyu capsules combined with Magnesium valproate sustained-release tablets was higher than that of magnesium valproate sustained-release tablets alone

and the effective output was also higher than that of Magnesium valproate sustained-release tablets alone. The incremental cost-effectiveness ratio was 7 051.79 yuan

about 0.22 times of the per capita disposable income of China in 2020. Sensitivity analysis showed that the results of this study were relatively stable. CONCLUSIONS: The willingness to pay threshold of the patients in this study is the per capita disposable income of China in 2020. Under this assumption

Xianyu capsules combined with Magnesium valproate sustained-release tablets is more economical than Magnesium valproate sustained-release tablets alone. Economic evaluation of Xianyu capsules in the treatment of epilepsy is conducive to rational allocation of medical resources and rational use of drugs by clinicians and patients.

关键词

痫愈胶囊癫痫药物经济学评价决策树模型丙戊酸镁缓释片

Keywords

Xianyu capsulesEpilepsyPharmacoeconomic evaluationDecision tree modelMagnesium valproate sustained-release tablets

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