Efficacy of Internal Iliac Artery Transcatheter Arterial Chemoembolization with Gemcitabine Combined with Cisplatin/Lobaplatin in the Treatment of Muscle Invasive Bladder Urothelial Carcinoma

DING Jin; ZENG Jianyong; LIU Ying; ZHOU Baicun; LIN Wenjing; TANG Guanlin

doi:10.14009/j.issn.1672-2124.2022.11.016

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Efficacy of Internal Iliac Artery Transcatheter Arterial Chemoembolization with Gemcitabine Combined with Cisplatin/Lobaplatin in the Treatment of Muscle Invasive Bladder Urothelial Carcinoma

更新时间：2023-04-16

- Efficacy of Internal Iliac Artery Transcatheter Arterial Chemoembolization with Gemcitabine Combined with Cisplatin/Lobaplatin in the Treatment of Muscle Invasive Bladder Urothelial Carcinoma
- Issue 11, Pages: 1353-1356(2022)
- 作者机构：
  
  1. 成都市第六人民医院药剂科
  2. 成都市第六人民医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.11.016
  CLC： R737.14
- Published：2022，
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DING Jin, ZENG Jianyong, LIU Ying, et al. Efficacy of Internal Iliac Artery Transcatheter Arterial Chemoembolization with Gemcitabine Combined with Cisplatin/Lobaplatin in the Treatment of Muscle Invasive Bladder Urothelial Carcinoma. [J]. (11):1353-1356(2022)
DOI：

DING Jin, ZENG Jianyong, LIU Ying, et al. Efficacy of Internal Iliac Artery Transcatheter Arterial Chemoembolization with Gemcitabine Combined with Cisplatin/Lobaplatin in the Treatment of Muscle Invasive Bladder Urothelial Carcinoma. [J]. (11):1353-1356(2022) DOI： 10.14009/j.issn.1672-2124.2022.11.016.

摘要

目的：探讨吉西他滨联合顺铂（GP）、吉西他滨联合洛铂（GL）髂内动脉化疗栓塞（TACE）治疗肌层浸润性膀胱尿路上皮癌的疗效。方法：选取2019年1月至2021年1月该院收治的浸润性膀胱尿路上皮癌患者104例，采用随机数字表法分为观察组和对照组。两组患者均接受TACE治疗，对照组52例患者予以GP方案，观察组52例患者予以GL方案。比较两组患者的临床疗效和不良反应，治疗前后肿瘤标志物、炎症反应和免疫功能。结果：观察组患者的疾病控制率为71.15%（37/52）

高于对照组的51.92%（27/52）

差异有统计学意义（P＜0.05）。观察组患者治疗后血清糖类抗原125、癌胚抗原水平低于对照组，血清白细胞介素（IL）6、IL-1β和肿瘤坏死因子α水平低于对照组，CD3

、CD4

和CD4

/CD8

水平高于对照组，差异均有统计学意义（P＜0.05）。观察组患者骨髓抑制、白细胞减少和恶心呕吐的发生率分别为11.54%（6/52）、38.46%（20/52）和26.92%（14/52）

低于对照组的26.92%（14/52）、59.62%（31/52）和48.08%（25/52）

差异均有统计学意义（P＜0.05）。结论：GL方案TACE治疗能改善浸润性膀胱尿路上皮癌患者肿瘤标志物水平，缓解炎症反应，调节免疫功能，减少不良反应，临床疗效确切。

Abstract

OBJECTIVE: To probe into the efficacy of internal iliac artery transcatheter arterial chemoembolization（TACE） with gemcitabine combined with cisplatin（GP） and gemcitabine combined with lobaplatin（GL） in the treatment of muscle invasive bladder urothelial carcinoma. METHODS: A total of 104 patients with invasive bladder urothelial carcinoma admitted into the hospital from Jan. 2019 to Jan. 2021 were extracted to be divided into the observation group and the control group via the random number table. Two groups were treated with TACE

52 patients in the control group were treated with GP regimen

and 52 patients in the observation group received GL regimen. The clinical efficacy and adverse drug reactions

tumor markers

inflammatory response and immune function before and after treatment were compared between two groups. RESULTS: The disease control rate of the observation group was 71.15%（37/52）

higher than 51.92%（27/52） of the control group

with statistically significant differences（P

0.05）. After treatment

the serum levels of CA125 and CEA in the observation group were lower than those in the control group

the serum levels of interleukin（IL）6

IL-1β and TNF-α were lower than those of the control group

and CD3

CD4

and CD4

/CD8

were higher than those of the control group

the differences were statistically significant（P

0.05）. The incidences of bone marrow suppression

leukopenia

nausea and vomiting in the observation group were respectively 11.54%（6/52）

38.46%（20/52） and 26.92%（14/52）

lower than 26.92%（14/52）

59.62%（31/52） and 48.08%（25/52） in the control group

the differences were statistically significant（P

0.05）. CONCLUSIONS: GL regimen TACE treatment can improve the level of tumor markers in patients with invasive bladder urothelial carcinoma

alleviate inflammatory response

regulate immune function and reduce adverse drug reactions with definite clinical efficacy.

关键词

肌层浸润性膀胱尿路上皮癌吉西他滨顺铂洛铂肿瘤标志物炎症反应免疫功能

Keywords

Muscle invasive bladder urothelial carcinomaGemcitabineCisplatinLobaplatinTumor markerInflammatory responseImmune function

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