OBJECTIVE: To probe into the effects of Shensong Yangxin capsules on hemorheology and cardiovascular function in patients with diabetic cardiovascular autonomic neuropathy of Qi and Yin deficiency. METHODS: A total of 130 patients with diabetic cardiovascular autonomic neuropathy of Qi and Yin deficiency admitted into Hai’an Hospital Affiliated to Nantong University from Jul. 2018 to Mar. 2020 were selected to be divided into control group and observation group by random number table method

with 65 cases in each group. The control group was given basic and nutritional treatment of diabetes

while the observation group was treated with Shensong Yangxin capsules. The clinical efficacy

changes of indicators of hemorheology

cardiovascular function and symptom scores

incidences of adverse cardiovascular events and adverse drug reactions of two groups were observed. RESULTS: After 12 weeks of treatment

the fibrinogen and D-dimer levels

the autonomic symptoms scale and composite autonomic symptoms score-31 in the observation group were significantly lower than those before treatment and in the control group

the QT dispersion and Valsalva action index in the observation group were significantly higher than those before treatment and in the control group

with statistically significant differences（P<0.05）. After 12 weeks of treatment

the total effective rate of the observation group was 95.38%（62/65）

which was higher than that of control group（83.08%

54/65）

with statistically significant difference（P<0.05）. After 6 months of follow-up

the incidences of cardiovascular adverse events of the observation group was 6.15%（4/65）

lower than 12.31%（8/65） of the control group

with statistically significant difference（P<0.05）. CONCLUSIONS: The application of Shensong Yangxin capsules on patients with diabetic cardiovascular autonomic neuropathy of Qi and Yin deficiency can improve patients’ hemorheology

promote cardiovascular function

relieve clinical symptoms

improve prognosis

with higher medication safety.