Efficacy of Ornidazole Sodium Chloride Injection in the Treatment of Bronchial Asthma Complicated with Infection and Its Effects on Clearance Rate of Pathogenic Bacteria

CAO Meiyan; HUANG Liang; LU Ping

doi:10.14009/j.issn.1672-2124.2022.11.009

您当前的位置：

首页 >

文章列表页 >

Efficacy of Ornidazole Sodium Chloride Injection in the Treatment of Bronchial Asthma Complicated with Infection and Its Effects on Clearance Rate of Pathogenic Bacteria

更新时间：2023-04-16

- Efficacy of Ornidazole Sodium Chloride Injection in the Treatment of Bronchial Asthma Complicated with Infection and Its Effects on Clearance Rate of Pathogenic Bacteria
- Issue 11, Pages: 1322-1325(2022)
- 作者机构：
  
  1. 湘南学院附属医院药剂科
  2. 湘南学院附属医院呼吸科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.11.009
  CLC： R562.25
- Published：2022，
扫描看全文
CAO Meiyan, HUANG Liang, LU Ping. Efficacy of Ornidazole Sodium Chloride Injection in the Treatment of Bronchial Asthma Complicated with Infection and Its Effects on Clearance Rate of Pathogenic Bacteria. [J]. (11):1322-1325(2022)
DOI：

CAO Meiyan, HUANG Liang, LU Ping. Efficacy of Ornidazole Sodium Chloride Injection in the Treatment of Bronchial Asthma Complicated with Infection and Its Effects on Clearance Rate of Pathogenic Bacteria. [J]. (11):1322-1325(2022) DOI： 10.14009/j.issn.1672-2124.2022.11.009.

摘要

目的：探讨奥硝唑氯化钠注射液治疗支气管哮喘（BA）合并感染的疗效及对病原菌清除率的影响。方法：按随机数字表法将2019年6月至2021年6月该院收治的BA合并感染患者86例分为研究组（43例）、对照组（43例）。对照组患者采用头孢哌酮钠他唑巴坦钠治疗，研究组患者在对照组的基础上加用奥硝唑氯化钠注射液治疗。比较两组患者的疗效、症状改善情况、细菌清除率及不良反应发生情况，治疗前后肺功能[用力肺活量（FVC）、第1秒用力呼气容积（FEV

）、最大呼气流速占预计值百分比（PEF%）和最大呼气中段流量（MMF）]、炎症因子[白细胞介素4（IL-4）、白细胞介素6（IL-6）和肿瘤坏死因子α（TNF-α）]

水平。结果：研究组患者的总有效率、细菌清除率分别为95.35%（41/43）、93.02%（40/43）

明显高于对照组的79.07%（34/43）、72.09%（31/43）

差异均有统计学意义（P＜0.05）。研究组患者症状改善时间较对照组更短，差异有统计学意义（P＜0.05）。治疗后，研究组患者血清IL-4、IL-6和TNF-α水平较对照组低，差异均有统计学意义（P＜0.05）。研究组、对照组患者不良反应发生率分别为16.28%（7/43）、6.98%（3/43）

差异无统计学意义（P＞0.05）。结论：奥硝唑氯化钠注射液治疗BA合并感染患者效果显著，可有效促使患者症状改善，提高细菌清除率，减轻机体炎症，改善肺功能，且安全性高。

Abstract

OBJECTIVE: To probe into the efficacy of ornidazole sodium chloride injection in the treatment of bronchial asthma（BA） complicated with infection and its effects on clearance rate of pathogenic bacteria. METHODS: A total of 86 patients with BA complicated with infection admitted into this hospital from Jun. 2019 to Jun. 2021 were selected and divided into research group（43 cases） and control group（43 cases） via the random number table. The control group was treated with cefoperazone sodium tazobactam sodium

while the research group was given ornidazole sodium chloride injection based on the control group. The efficacy

symptom improvement

bacterial clearance rate and incidences of adverse drug reactions

pulmonary function [forced vital capacity（FVC）

forced expiratory volume in 1 s（FEV

）

proportion of peak expiratory flow accounted for its predicted value（PEF%） and maximum mid-expiratory flow（MMF）] and inflammatory factors levels [interleukin 4（IL-4）

interleukin 6（IL-6） and tumor necrosis factor α（TNF-α）]

before and after treatment were compared between two groups. RESULTS: The total effective rate and bacterial clearance rate of research group were respectively 95.35%（41/43） and 93.02%（40/43）

significantly higher than those of the control group（79.07%

34/43; 72.09%

31/43）

with statistically significant differences（P

0.05）. The symptom improvement time of research group was shorter than that of the control group

with statistically significant difference（P

0.05）. After treatment

the serum IL-4

IL-6 and TNF-α levels of research group were significantly lower than those of the control group

with statistically significant differences（P

0.05）. The incidences of adverse drug reactions of research group and control group were respectively 16.28%（7/43） and 6.98%（3/43）

the difference was not statistically significant（P

0.05）. CONCLUSIONS: The efficacy of ornidazole sodium chloride injection in the treatment of BA complicated with infection is remarkable

which can promote symptom improvement

increase bacterial clearance rate

relieve body inflammation and improve pulmonary function

with high safety.

关键词

支气管哮喘奥硝唑氯化钠注射液病原菌清除率感染免疫功能

Keywords

Bronchial asthmaOrnidazole sodium chloride injectionPathogen clearance rateInfectionImmune function

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Efficacy of Internal Iliac Artery Transcatheter Arterial Chemoembolization with Gemcitabine Combined with Cisplatin/Lobaplatin in the Treatment of Muscle Invasive Bladder Urothelial Carcinoma

Effects of Fiberoptic Bronchoalveolar Lavage Combined with Azithromycin on Immune Function, Serum MCP-4, MAPK and CysLTR1 in Children with Mycoplasma Pneumoniae Pneumonia

Effects of Qingre Huatan Decoction Combined with Sangbaipi Decoction on Pulmonary Ventilation Function and Immune Function in Patients with Chronic Obstructive Pulmonary Disease of Phlegm-Heat Stagnation Type

Effects of Danshen Ligustrazine Injection Combined with EC-T Regimen on Short-Term Efficacy, Immune Function and Quality of Life in Patients with Breast Cancer After Surgery

Systematic Review of Bufei Yishen Method for the Treatment of Bronchial Asthma in Remission Stage

Related Author

TANG Guanlin

LIN Wenjing

ZHOU Baicun

LIU Ying

ZENG Jianyong

DING Jin

ZHANG Juan

ZHAO Dongmei

Related Institution

Dept. of Urology, Chengdu Sixth People’s Hospital

Dept. of Pharmacy, Chengdu Sixth People’s Hospital

Pediatric Intensive Care Unit, Chengdu Women’s and Children’s Central Hospital

Dept. of Pediatrics, Nanchong Central Hospital

Drug Clinical Trial Institute, Heze Hospital of Traditional Chinese Medicine

⁰