Extracorporal Incompatibility of Esomeprazole with Single Intravenous Access Continuous Pumping of Somatostatin and Literature Review

PANG Guoxun; YAN Bin; JIN Huixin; WANG Zhiheng

doi:10.14009/j.issn.1672-2124.2022.11.007

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Extracorporal Incompatibility of Esomeprazole with Single Intravenous Access Continuous Pumping of Somatostatin and Literature Review

更新时间：2023-04-16

- Extracorporal Incompatibility of Esomeprazole with Single Intravenous Access Continuous Pumping of Somatostatin and Literature Review
- Issue 11, Pages: 1315-1317(2022)
- 作者机构：
  
  河北省人民医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.11.007
  CLC： R969.3
- Published：2022，
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PANG Guoxun, YAN Bin, JIN Huixin, et al. Extracorporal Incompatibility of Esomeprazole with Single Intravenous Access Continuous Pumping of Somatostatin and Literature Review. [J]. (11):1315-1317(2022)
DOI：

PANG Guoxun, YAN Bin, JIN Huixin, et al. Extracorporal Incompatibility of Esomeprazole with Single Intravenous Access Continuous Pumping of Somatostatin and Literature Review. [J]. (11):1315-1317(2022) DOI： 10.14009/j.issn.1672-2124.2022.11.007.

摘要

目的：完善艾司奥美拉唑与生长抑素配伍使用的稳定性资料，为临床合理用药提供理论支撑。方法：检索中国知网、万方数据库和PubMed等数据库，汇总艾司奥美拉唑和生长抑素配伍使用稳定性的相关文献；并基于临床应用的真实场景，进行两种药物配伍使用的基础实验研究。结果：共纳入与两种药物体外配伍相关的文献7篇，提示艾司奥美拉唑与生长抑素等多种药物配伍可发生颜色变化或产生沉淀；基础实验灯检结果显示，配伍液1 h出现结晶，4 h出现肉眼可见微粒。结论：艾司奥美拉唑与生长抑素的pH相差较大，存在配伍禁忌，为保证静脉用药安全，不宜共用单个静脉通道持续泵入，建议分开单独使用，或与其他药物共用静脉通道。

Abstract

OBJECTIVE: To improve the stability data for the compatibility of esomeprazole with somatostatin

so as to provide theoretical support for the rational clinical application. METHODS: Literature related to the stability of compatibility of esomeprazole with somatostatin were retrieved from CNKI

Wanfang Data and PubMed. The basic experimental study on the compatibility of two drugs was conducted based on the real scenario of clinical application. RESULTS: A total of 7 papers related to the extracorporal compatibility of the two drugs were enrolled

which suggested that color change or precipitation can occur in the compatibility of esomeprazole with somatostatin and other drugs. Results of basic experimental light inspection showed that crystals appeared in the compatibility solution at 1 h and the particles were visible to naked eye at 4 h. CONCLUSIONS: The difference of pH between esomeprazole and somatostatin is large

so that there are incompatibilities. To ensure the safety of intravenous drug administration

it is not advisable to share a single intravenous access for continuous pumping

and it is recommended to apply separately or share the intravenous access with other drugs.

关键词

艾司奥美拉唑生长抑素配伍禁忌持续泵入静脉通道

Keywords

EsomeprazoleSomatostatinIncompatibilityContinuous pumpingIntravenous access

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