OBJECTIVE: To analyze the application of antidiabetic drugs through spot check on routine medication in inpatients with type 2 diabetes mellitus（T2DM）

so as to provide reference for clinical practice. METHODS: Retrospective analysis method was adopted

totally 100 medical records were randomly extracted from inpatients with T2DM in the endocrinology department of a Class Ⅲ Grade A hospital in 2021

the general information

therapeutic regimens and blood glucose levels were collected to analyze the application of antidiabetic drug and evaluate its rationality. RESULTS: In the 100 medical records of T2DM inpatients

totally 26 kinds of antidiabetic drugs were used

among which the top 4 drugs ranked by frequency of application were acarbose tablets

metformin hydrochloride tablets

insulin aspart injection and dapagliflozin tablets; the proportion of patients with drug combination was 95%（95 cases）

mainly were three-drug and four-drug combination

the most common therapeutic regimen was insulin intensive therapy combined with other antidiabetic drugs with different mechanisms of action. Meanwhile

it was also found that some patients had irrational drug combination（5 cases

5%）

irrational medication frequency（3 cases

3%） and irrational medication dose（1 case

1%）. The patients’ blood glucose level at discharge was significantly better than that at admission

with statistically significant difference（P<0.05）

but some patients had not fully reached the standard. CONCLUSIONS: The application of antidiabetic drugs is basically reasonable in 91% patients with T2DM

the new oral hypoglycemic drug dapagliflozin is used more frequently and the combined application of antidiabetic drugs is common. However

9% of patients still have irrational medication

and about 40% of patients’ blood glucose levels have not fully reached the standard

which require targeted strategies to improve the rationality and effectiveness of clinical medication.