Systematic Review of Efficacy and Safety of Azelastine Hydrochloride Combined with Mometasone Furoate in the Treatment of Allergic Rhinitis

doi:10.14009/j.issn.1672-2124.2022.10.015

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Systematic Review of Efficacy and Safety of Azelastine Hydrochloride Combined with Mometasone Furoate in the Treatment of Allergic Rhinitis

更新时间：2023-04-16

- Systematic Review of Efficacy and Safety of Azelastine Hydrochloride Combined with Mometasone Furoate in the Treatment of Allergic Rhinitis
- Vol. 22, Issue 10, Pages: 1220-1223(2022)
- 作者机构：
  
  1. 北京医院药学部国家老年医学中心中国医学科学院老年医学研究院北京市药物临床风险与个体化应用评价重点实验室(北京医院)
  2. 北京医院检验科国家老年医学中心中国医学科学院老年医学研究院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.10.015
  CLC： R765.21
- Published：2022，
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Systematic Review of Efficacy and Safety of Azelastine Hydrochloride Combined with Mometasone Furoate in the Treatment of Allergic Rhinitis. [J]. 22(10):1220-1223(2022)
DOI：

Systematic Review of Efficacy and Safety of Azelastine Hydrochloride Combined with Mometasone Furoate in the Treatment of Allergic Rhinitis. [J]. 22(10):1220-1223(2022) DOI： 10.14009/j.issn.1672-2124.2022.10.015.

摘要

目的：系统评价盐酸氮卓斯汀联合糠酸莫米松治疗变应性鼻炎的有效性和安全性。方法：计算机检索万方数据库、中国知网、百度文库、Embase、the Cochrane Library和PubMed等数据库，纳入评价盐酸氮卓斯汀联合糠酸莫米松治疗变应性鼻炎的随机对照试验(RCT

研究组和对照组患者分别使用盐酸氮卓斯汀联合糠酸莫米松治疗和单独使用糠酸莫米松治疗)

检索时间为建库至2022年9月。由2名研究者提取资料、选取文献并评价纳入文章的偏倚风险后，采用RevMan 5.4软件进行Meta分析。结果：共纳入8项RCT研究，包括809例患者，其中研究组患者405例，对照组患者404例。Meta分析结果显示，有效性方面，采用盐酸氮卓斯汀联合糠酸莫米松治疗的研究组变应性鼻炎患者在总有效率(OR=4.11

95%CI=2.75～6.16

P<0.000 01)、显效率(OR=2.12

95%CI=1.59～2.82

P<0.000 01)、鼻部症状评分(MD=-1.33

95%CI=-1.45～-1.21

P<0.000 01)和白细胞介素4水平(MD=-5.58

95%CI=-6.38～-4.78

P<0.000 01)等方面均显著优于单独使用糠酸莫米松治疗的对照组患者，差异均有统计学意义；不良反应方面，研究组与对照组患者不良反应发生率的差异无统计学意义(OR=1.19

95%CI=0.66～2.15

P=0.56)。结论：现有证据表明，盐酸氮卓斯汀联合糠酸莫米松治疗变应性鼻炎安全、有效，较单独使用糠酸莫米松有明显优势。因选取的RCT数量和质量的限制，上述结论有待今后更多高质量RCT予以验证。

Abstract

OBJECTIVE: To systematically evaluate the efficacy and safety of azelastine hydrochloride combined with mometasone furoate in the treatment of allergic rhinitis. METHODS: Wanfang Data

CNKI

Baidu Library

Embase

the Cochrane Library

PubMed and other databases were retrieved to collect the randomized controlled trial（RCT） of azelastine hydrochloride combined with mometasone furoate in the treatment of allergic rhinitis（the study group and control group were respectively treated with azelastine hydrochloride combined with mometasone furoate and mometasone furoate alone）. The retrieval time was from the establishment of the database to Sept. 2022. Meta-analysis was performed by using RevMan 5.4 software after data extraction

selection of literature and evaluation of risk of bias of included literature by two investigators. RESULTS: Totally 8 RCT were enrolled

including 809 patients

with 405 patients in the study group and 404 patients in the control group. Meta-analysis showed that in terms of effectiveness

the total effective rate（OR=4.11

95%CI=2.75-6.16

P<0.000 01） and significant effective rate（OR=2.12

95%CI=1.59-2.82

P<0.000 01）

nasal symptom score（MD=-1.33

95%CI=-1.45--1.21

P<0.000 01） and interleukin-4 level（MD=-5.58

95%CI=-6.38--4.78

P<0.000 01） of allergic rhinitis patients in the study group treated with azelastine hydrochloride combined with mometasone furoate were significantly better than those in the control group treated with mometasone furoate alone

with statistically significant differences. There was no significant difference in the incidence of adverse drug reactions between the study group and the control group（OR=1.19

95%CI=0.66-2.15

P=0.56）. CONCLUSIONS: Available evidence suggests that azelnostine hydrochloride combined with mometasone furoate is safe and effective in the treatment of allergic rhinitis

with significant advantages over mometasone furoate alone. Due to the limitation of the number and quality of the selected RCT

the above conclusions need to be validated by more high-quality RCT in the future.

关键词

盐酸氮卓斯汀糠酸莫米松变应性鼻炎Meta分析随机对照试验

Keywords

Azelastine hydrochlorideMometasone furoateAllergic rhinitisMeta-analysisRandomized controlled trial

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