OBJECTIVE: To observe the effectiveness of participation of pharmacists in pain management of knee replacement under accelerated rehabilitation. METHODS: From Jun. 2018 to Jun. 2021

120 patients underwent knee replacement in the orthopedics department of the hospital were randomly divided into the observation group and the control group

with 60 cases in each group. The control group received conventional pain management after surgery

while the observation group was given postoperative pain management with the participation of clinical pharmacists. Differences in postoperative pain scores

sleep quality

irrational drug use

adverse drug reactions

length of stay

and hospitalization cost were compared between two groups. RESULTS: The pain score and sleep quality indicators in the observation group were significantly lower than those in the control group from 1 to 7 d after surgery

and the differences were statistically significant（P<0.05）. After surgery

the irrational use rate of analgesics and incidence of adverse drug reactions in the observation group were significantly lower than those in the control group

the differences were statistically significant（P<0.05）. Compared with the control group

the length of stay in the observation group was shortened from（14.4±4.2） d to（12.9±3.3） d

and the cost of analgesics per capita was reduced from（1 796.0±779.7） yuan to（1 030.3±409.7） yuan

the differences were statistically significant（P<0.05）. CONCLUSIONS: Participation of clinical pharmacists in pain management can accelerate the patient recovery

effectively improve the postoperative analgesia and sleep quality

reduce the adverse drug reactions

shorten the length of stay and reduce the hospitalization cost.