OBJECTIVE: To probe into the effects of ginkgo biloba extract injection combined with conventional treatment on vascular regeneration and collateral circulation after cerebral infarction. METHODS: Totally 80 patients with acute cerebral infarction admitted into the hospital from Mar. 2018 to Dec. 2021 were extracted to be divided into the control group and observation group via the random number table method

with 40 cases in each group. The control group was given conventional treatment according to the guidelines

while the observation group received ginkgo biloba extract injection based on the control group. After treatment of 28 d

the serum levels of vascular endothelial growth factor（VEGF）

angiopoietin（Ang）

basic fibroblast growth factor（bFGF）

American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology（ASITN/SIR） lateral circulation classification

National Institutes of Health Stroke Scale（NIHSS）

Montreal cognitive assessment（MoCA）

mini-mental state examination（MMSE）

modified Rankin（mRS） score and adverse drug reactions were observed in both groups. RESULTS: After treatment

compared with before treatment

the serum levels of VEGF

Ang

bFGF

MOCA and MMSE scores increased

ASITN/SIR lateral circulation classification was improved

and NIHSS score decreased

with statistically significant differences（P<0.05）. After treatment

the serum levels of VEGF [（52.31±11.59） pg/mL vs.（43.15±9.37） pg/mL]

Ang [（23.15±4.57） ng/mL vs.（19.35±3.78） ng/mL]

bFGF [（16.31±4.11） ng/L vs.（13.08±3.42） ng/L]

MoCA [（28.15±1.02） points vs.（25.34±2.69） points] and MMSE [（27.42±2.03） points vs.（24.43±3.72） points] in the observation group were higher than those in the control group

the ASITN/SIR lateral circulation classification was better than that in the control group

the NIHSS score [（8.12±2.03） points vs.（11.24±2.68） points] and mRS score [（2.01±0.69） points vs.（3.75±0.85） points] were lower than those in the control group

with statistically significant differences（P<0.05）. There was no significant difference in the incidence of adverse drug reactions between the observation group and the control group [7.50%（3/40） vs. 10.00%（4/40）

P>0.05]. CONCLUSIONS: Ginkgo biloba extract injection can promote the regeneration of cerebral infarction and the establishment of collateral circulation

improve the neurological and cognitive function and prognosis of patients.