OBJECTIVE: To probe into the effects of Gukang capsules combined with alendronate sodium on bone healing and bone metabolism in patients with osteoporotic compression fracture after balloon dilatation percutaneous kyphoplasty（PKP）. METHODS: Data of 118 patients with osteoporotic compression fractures who underwent balloon PKP in Sichuan Integrative Medicine Hospital from Jan. 2020 to Sept. 2021 were retrospectively analyzed

which were divided into the alendronate sodium group（58 cases

treated with alendronate sodium） and the combination group（60 cases

treated with Gukang capsules combined with alendronate sodium） according to different therapeutic regimens after surgery. The efficacy after treatment

indicators of bone mineral density and bone metabolism [serum bone alkaline phosphatase（BALP）

tartrate-resistant acid phosphatase-5 b（TRACP-5 b）

urinary deoxypyridinoline（D-Pyr）

total propeptide of procollagen Ⅰ（tPⅠNP） and beta-isomer of the C-terminal telopeptide of type Ⅰ collagen（β-CTX）]

and various scores [visual analogue scale（VAS） score

Japanese orthopaedic association（JOA） score]

before and after treatment were compared between two groups. RESULTS: The total effective rates of combination group and alendronate sodium group were respectively 95.00%（57/60） and 81.03%（47/58）

the difference was statistically significant（P

<

0.05）. After treatment

the indicators of bone mineral density and bone metabolism

VAS scores and JOA scores of both groups were significantly improved compared with those before treatment

with statistically significant differences（P

<

0.05）. After treatment

the bone mineral density of femoral neck

greater trochanter

lumbar vertebra L

2—4

and Ward triangle of combination group were significantly higher than those of the alendronate sodium group; after treatment

the bone metabolism indicators of BALP

TRACP-5 b

D-Pyr and β-CTX of combination group were significantly lower than those of the alendronate sodium group

while the tPⅠNP level was significantly higher than that of the alendronate sodium group; after treatment

the VAS score of combination group was significantly lower than that of the alendronate sodium group

while the JOA score was significantly higher than that of the alendronate sodium group

with statistically significant differences（P

<

0.05）. CONCLUSIONS: The efficacy of Gukang capsules combined with alendronate sodium in the treatment of patients with osteoporotic compression fracture undergoing balloon dilatation PKP is remarkable

which can effectively improve bone mineral density and bone metabolism

relieve postoperation pain

and accelerate bone healing.