Progress of Neurotoxicity Induced by Irrational Use of Sophorae tonkinensis Radix et Rhizoma

LIU Tiantian; ZHANG Yanli; MA Lina; MAO Liuying; HE Ting; CAO Junling

doi:10.14009/j.issn.1672-2124.2022.09.028

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Progress of Neurotoxicity Induced by Irrational Use of Sophorae tonkinensis Radix et Rhizoma

更新时间：2023-04-16

- Progress of Neurotoxicity Induced by Irrational Use of Sophorae tonkinensis Radix et Rhizoma
- Vol. 22, Issue 9, Pages: 1149-1152(2022)
- 作者机构：
  
  北京中医药大学东方医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.09.028
  CLC： R285
- Published：2022，
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LIU Tiantian, ZHANG Yanli, MA Lina, et al. Progress of Neurotoxicity Induced by Irrational Use of Sophorae tonkinensis Radix et Rhizoma. [J]. 22(9):1149-1152(2022)
DOI：

LIU Tiantian, ZHANG Yanli, MA Lina, et al. Progress of Neurotoxicity Induced by Irrational Use of Sophorae tonkinensis Radix et Rhizoma. [J]. 22(9):1149-1152(2022) DOI： 10.14009/j.issn.1672-2124.2022.09.028.

摘要

山豆根为临床常用中药，具有抑菌、抗炎、抗氧化、抗肿瘤、抗病毒、保肝及调节免疫等多种药理作用，在临床被用于治疗肿瘤、咽喉炎症和肝炎等疾病。但其不良反应时有报道。毒理学研究发现，山豆根服用剂量过大可对消化系统、神经系统、呼吸系统、血液系统、心血管系统和肝胆系统等产生毒性反应。其中以神经毒性最严重，危害最大。本文主要对山豆根致中毒性脑病的化学成分、影像学表现、不合理使用(超剂量、超疗程、煎煮时间长以及不合理配伍)致神经毒性发生、潜在作用机制、中毒预防措施及中毒后救治方法进行综述，为进一步深入探究山豆根的药理毒理机制和临床合理使用、避免毒性发生提供参考。

Abstract

Sophorae tonkinensis Radix et Rhizoma is a commonly used traditional Chinese medicine in clinic. It has various pharmacological effects such as antibacterial

anti-inflammatory

antioxidant

anti-tumor

anti-viral

liver protection and immune regulation. It is clinically used to treat tumors

pharyngeal inflammation

hepatitis and other diseases. However

the adverse drug reactions are commonly reported. Toxicological studies have found that excessive dosage of Sophorae tonkinensis Radix et Rhizoma can bring toxic reactions to digestive system

nervous system

respiratory system

blood system

cardiovascular system and hepatobiliary system

etc. Among them

neurotoxicity is the most severe and harmful. This paper mainly reviews the chemical composition

imaging manifestations

neurotoxicity induced by irrational use（off-label dose

off-label course of treatment

long decoction time and irrational compatibility）

potential mechanism of action

poisoning prevention measures and post poisoning treatment methods

so as to provide reference for further exploring the pharmacological and toxicological mechanism

clinical rational use and avoiding toxicity of Sophorae tonkinensis Radix et Rhizoma.

关键词

山豆根不合理用药神经毒性中毒性脑病研究进展

Keywords

Sophorae tonkinensis Radix et RhizomaIrrational drug useNeurotoxicityToxication encephalopathyResearch progress

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