Comparative Analysis on Adverse Drug Reactions Between Ibuprofen and Acetaminophen

GU Tongtong; ZHANG Hang; CHENG Chuhao; HUANG Beibei

doi:10.14009/j.issn.1672-2124.2022.09.027

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Comparative Analysis on Adverse Drug Reactions Between Ibuprofen and Acetaminophen

更新时间：2023-04-16

- Comparative Analysis on Adverse Drug Reactions Between Ibuprofen and Acetaminophen
- Vol. 22, Issue 9, Pages: 1145-1148(2022)
- 作者机构：
  
  1. 复旦大学附属金山医院临床药学室
  2. 上海交通大学医学院附属第一人民医院胸外科
  3. 南京医科大学药学院
  4. 徐州医科大学附属医院国家药物临床试验机构办公室
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.09.027
  CLC： R969
- Published：2022，
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GU Tongtong, ZHANG Hang, CHENG Chuhao, et al. Comparative Analysis on Adverse Drug Reactions Between Ibuprofen and Acetaminophen. [J]. 22(9):1145-1148(2022)
DOI：

GU Tongtong, ZHANG Hang, CHENG Chuhao, et al. Comparative Analysis on Adverse Drug Reactions Between Ibuprofen and Acetaminophen. [J]. 22(9):1145-1148(2022) DOI： 10.14009/j.issn.1672-2124.2022.09.027.

摘要

目的：了解布洛芬、对乙酰氨基酚的药品不良反应(ADR)发生规律和临床特点。方法：分别检索万方数据库、中国知网和PubMed等数据库(检索时间为2000年1月至2021年11月)

收集布洛芬、对乙酰氨基酚的ADR文献，并进行统计分析。结果：筛选得到文献135篇，其中关于布洛芬的ADR文献51篇，关于对乙酰氨基酚的ADR文献84篇。在布洛芬的51例ADR报告中，患者年龄主要为≥70岁(15例，占29.4%);原患疾病主要为关节炎及关节疼痛(22例，占43.1%);ADR多发生于用药后≤1 d(30例，占58.8%);ADR累及器官和(或)系统共128例次，其中消化系统损害(37例次，占总例次数的28.9%)、皮肤及其附件损害(36例次，占总例次数的28.1%)多见；恢复时间集中于0～3 d(19例，占37.3%)。在对乙酰氨基酚的84例ADR报告中，患者年龄主要为<10岁(29例，占34.5%);原患疾病多为上呼吸道感染、发热(56例，占66.7%);ADR多发生于用药后>1～7 d(45例，占53.6%);ADR累及器官和(或)系统共258例次，其中皮肤及其附件(109例次，占总例次数的42.2%)和消化系统(49例次，占总例次数的19.0%)的损害多见；恢复时间集中于>7～30 d(42例，占50.0%)。结论：布洛芬与对乙酰氨基酚的ADR在年龄分布、原患疾病、ADR发生时间、脏器损害和恢复时间等方面存在差异。在严重的ADR方面，药物过敏反应和急性肝损伤应引起临床重视。

Abstract

OBJECTIVE: To investigate the occurrence regularity and clinical characteristics of adverse drug reactions（ADR） of ibuprofen and acetaminophen. METHODS: Literature about ADR of ibuprofen and acetaminophen were retrieved from Wanfang Data

CNKI and PubMed（the search time: from Jan. 2000 to Nov. 2021）

and then all literature were statistically analyzed. RESULTS: Totally 135 studies were screened

including 51 ADR studies about ibuprofen and 84 ADR studies about acetaminophen. Among the 51 ADR reports of ibuprofen

the patients were mainly aged ≥70 years old（15 cases

29.4%）; the primary diseases were mainly arthritis and joint pain（22 cases

43.1%）; ADR mainly occurred in ≤1 d after drug administration（30 cases

58.8%）; ADR had involved organs and（or） systems in 128 case-times

including digestive system damage（37 case-times

accounting for 28.9% of the total case-times）

skin and its accessories damage（36 case-times

accounting for 28.1% of the total case-times）; the recovery time was concentrated in 0 to 3 d（19 cases

37.3%）. Among the 84 ADR reports of acetaminophen

the patients were mainly aged <10 years old（29 cases

34.5%）; the primary diseases were mainly upper respiratory tract infection and fever（56 cases

66.7%）; ADR mainly occurred more than 1 to 7 d after treatment（45 cases

53.6%）; ADR had involved organs and（or） systems in 258 case-times

of which the skin and its accessories（109 case-times

accounting for 42.2% of the total case-times） and digestive system（49 case-times

accounting for 19.0% of the total case-times） were more common; the recovery time was concentrated in >7 to 30 d（42 cases

50.0%）. CONCLUSIONS: There are differences in ADR between ibuprofen and acetaminophen in terms of age distribution

primary disease

ADR occurrence time

organ damage and recovery time. In severe ADR

drug anaphylaxis and acute liver injury should be paid attention to.

关键词

布洛芬对乙酰氨基酚药品不良反应文献分析

Keywords

IbuprofenParacetamolAdverse drug reactionsLiterature analysis

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