Systematic Review of Efficacy and Safety of Dantian Jiangzhi Pills Combined with Statins in the Treatment of Hyperlipidemia

LIU Wei; LI Xingxing; FAN Zongjing; CUI Jie; WU Yang

doi:10.14009/j.issn.1672-2124.2022.09.024

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Systematic Review of Efficacy and Safety of Dantian Jiangzhi Pills Combined with Statins in the Treatment of Hyperlipidemia

更新时间：2023-04-16

- Systematic Review of Efficacy and Safety of Dantian Jiangzhi Pills Combined with Statins in the Treatment of Hyperlipidemia
- Vol. 22, Issue 9, Pages: 1134-1137(2022)
- 作者机构：
  
  1. 北京中医药大学第二临床医学院
  2. 北京中医药大学东方医院心血管科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.09.024
  CLC： R589.2
- Published：2022，
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LIU Wei, LI Xingxing, FAN Zongjing, et al. Systematic Review of Efficacy and Safety of Dantian Jiangzhi Pills Combined with Statins in the Treatment of Hyperlipidemia. [J]. 22(9):1134-1137(2022)
DOI：

LIU Wei, LI Xingxing, FAN Zongjing, et al. Systematic Review of Efficacy and Safety of Dantian Jiangzhi Pills Combined with Statins in the Treatment of Hyperlipidemia. [J]. 22(9):1134-1137(2022) DOI： 10.14009/j.issn.1672-2124.2022.09.024.

摘要

目的：系统评价丹田降脂丸联合他汀类药物治疗高脂血症的疗效性与安全性。方法：通过检索中外数据库，纳入有关丹田降脂丸联合他汀类药物治疗高脂血症的临床随机对照试验(对照组患者给予他汀类药物，如阿托伐他汀、瑞舒伐他汀和辛伐他汀等；研究组患者在对照组基础上加用丹田降脂丸；剂量、疗程不限)。使用RevMan 5.3软件对数据进行统计分析。结果：共纳入9项随机对照试验，涉及1 152例患者。分析结果显示，研究组患者的总有效率高于对照组(OR=3.38

95%CI=2.18～5.26

P<0.000 01)

血总胆固醇(MD=-0.89

95%CI=-1.34～-0.43

P=0.000 2)、三酰甘油(MD=-0.66

95%CI=-1.03～-0.30

P=0.000 3)、低密度脂蛋白胆固醇(MD=-0.61

95%CI=-0.97～-0.25

P=0.000 9)和高密度脂蛋白胆固醇(MD=0.28

95%CI=0.16～0.41

P<0.000 01)等指标水平改善程度优于对照组，上述差异均有统计学意义。研究组患者无明显不良反应。结论：丹田降脂丸联合他汀类药物用于高脂血症的治疗安全、有效。

Abstract

OBJECTIVE: To systematically evaluate the efficacy and safety of Dantian Jiangzhi pills combined with statins in the treatment of hyperlipidemia. METHODS: By searching Chinese and foreign databases

clinical randomized controlled trials of Dantian Jiangzhi pills combined with statins in the treatment of hyperlipidemia were included（the control group was given statins such as atorvastatin

resulvastatin and simvastatin; the study group received Dantian Jiangzhi pills based on the control group; the dose and duration of treatment were not limited）. RevMan 5.3 was used to analyze the data of the included literature. RESULTS: Totally 9 randomized controlled trials were enrolled

including 1 152 patients. The total effective rate of the study group was higher than that of the control group（OR=3.38

95%CI=2.18-5.26

P<0.000 01）

serum TC（MD=-0.89

95%CI=-1.34--0.43

P=0.000 2） and TG（MD=-0.66

95%CI=-1.03--0.30

P=0.000 3）

LDL-C（MD=-0.61

95%CI=-0.97--0.25

P=0.000 9） and HDL-C（MD=0.28

95%CI=0.16-0.41

P<0.000 01） were better than those in the control group

and the differences were statistically significant. The study group had no obvious adverse drug reactions. CONCLUSIONS: Dantian Jiangzhi pills combined with statins are safe and effective in the treatment of hyperlipidemia.

关键词

丹田降脂丸他汀类药物高脂血症Meta分析

Keywords

Dantian Jiangzhi pillsStatinsHyperlipidemiaMeta-analysis

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