Efficacy of Compound Zaofan Pills Combined with Recombinant Human Granulocyte Colony-Stimulating Factor in the Treatment of Leukopenia After Tumor Chemotherapy

SANG Yuanyuan; WANG Xiaoling; SUN Li; FENG Cuiying; LIN Ziwei

doi:10.14009/j.issn.1672-2124.2022.09.011

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Efficacy of Compound Zaofan Pills Combined with Recombinant Human Granulocyte Colony-Stimulating Factor in the Treatment of Leukopenia After Tumor Chemotherapy

更新时间：2023-04-16

- Efficacy of Compound Zaofan Pills Combined with Recombinant Human Granulocyte Colony-Stimulating Factor in the Treatment of Leukopenia After Tumor Chemotherapy
- Vol. 22, Issue 9, Pages: 1072-1074(2022)
- 作者机构：
  
  1. 亳州市人民医院药学部
  2. 亳州市人民医院肾内科
  3. 亳州市人民医院肿瘤科
  4. 亳州市人民医院老年科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.09.011
  CLC： R730.53
- Published：2022，
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SANG Yuanyuan, WANG Xiaoling, SUN Li, et al. Efficacy of Compound Zaofan Pills Combined with Recombinant Human Granulocyte Colony-Stimulating Factor in the Treatment of Leukopenia After Tumor Chemotherapy. [J]. 22(9):1072-1074(2022)
DOI：

SANG Yuanyuan, WANG Xiaoling, SUN Li, et al. Efficacy of Compound Zaofan Pills Combined with Recombinant Human Granulocyte Colony-Stimulating Factor in the Treatment of Leukopenia After Tumor Chemotherapy. [J]. 22(9):1072-1074(2022) DOI： 10.14009/j.issn.1672-2124.2022.09.011.

摘要

目的：探讨复方皂矾丸联合重组人粒细胞刺激因子(rhG-CSF)治疗肿瘤化疗后白细胞减少症的疗效。方法：选取2021年该院收治的94例化疗后白细胞减少症患者，根据随机数字表法分为对照组和观察组，每组47例。对照组患者接受rhG-CSF治疗，观察组患者接受复方皂矾丸联合rhG-CSF治疗。比较两组患者的临床疗效，中医证候积分，不良反应发生情况，外周血白细胞计数(WBC)、中性粒细胞计数(NEUT)

CD3~+、CD4~+、CD8~+和CD4~+/CD8~+水平。结果：观察组患者的总有效率为89.36%(42/47)

明显高于对照组的72.34%(34/47)

差异有统计学意义(P<0.05)。治疗后，两组患者中医证候积分和外周血CD8~+水平明显降低，外周血WBC、NEUT、CD3~+、CD4~+和CD4~+/CD8~+水平明显升高；且观察组患者中医证候积分和外周血CD8~+水平明显低于对照组，外周血WBC、NEUT、CD3~+、CD4~+和CD4~+/CD8~+水平明显高于对照组，差异均有统计学意义(P<0.05)。对照组、观察组患者的不良反应发生率分别为17.02%(8/47)、12.77%(6/47)

两组比较的差异无统计学意义(P>0.05)。结论：复方皂矾丸联合rhG-CSF治疗肿瘤化疗后白细胞减少症的疗效显著，能有效提升白细胞数量，改善免疫功能，且安全性高。

Abstract

OBJECTIVE: To probe into the efficacy of compound Zaofan pills combined with recombinant human granulocyte colony-stimulating factor（rhG-CSF） in the treatment of leukopenia after tumor chemotherapy. METHODS: A total of 94 patients with leukopenia after tumor chemotherapy admitted into the hospital in 2021 were extracted to be divided into the control group and the observation group via the random number table method

with 47 cases in each group. The control group received rhG-CSF treatment

while the observation group was given compound Zaofan pills combined with rhG-CSF treatment. The clinical efficacy

traditional Chinese medicine syndrome score

incidence of adverse drug reactions

peripheral blood white blood cell（WBC） count

neutrophil count（NEUT）

CD3

CD4

CD8

and CD4

/CD8

were compared between two groups. RESULTS: The total effective rate of the observation group was 89.36%（42/47）

significantly higher than 72.34%（34/47） of the control group

the difference was statistically significant（P

0.05）. After treatment

the traditional Chinese medicine syndrome score and peripheral blood CD8

levels decreased significantly

while peripheral blood WBC

NEUT

CD3

CD4

and CD4

/CD8

levels increased significantly in two groups; the traditional Chinese medicine syndrome score and peripheral blood CD8

levels of the observation group were significantly lower than those of the control group

and the peripheral blood WBC

NEUT

CD3

CD4

and CD4

/CD8

levels of the observation group were significantly higher than those of the control group

the differences were statistically significant（P

0.05）. The incidence of adverse drug reactions in the control group and the observation group were respectively 17.02%（8/47） and 12.77%（6/47）

and there was no significant difference between two groups（P

0.05）. CONCLUSIONS: The efficacy of Zaofan pills combined with rhG-CSF in the treatment of leukopenia after tumor chemotherapy is significant

which can effectively increase the WBC and improve the immune function with higher safety.

关键词

化疗白细胞减少症复方皂矾丸重组人粒细胞刺激因子

Keywords

ChemotherapyLeukopeniaCompound Zaofan pillsRecombinant human granulocyte colony-stimulating factor

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