Blood Concentration Monitoring of Digoxin in A Hospital and Its Influencing Factors

HUANG Jinghui; ZHAO Yan; YANG Zhihui; YUAN Hailong; ZHANG Lili

doi:10.14009/j.issn.1672-2124.2022.08.018

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Blood Concentration Monitoring of Digoxin in A Hospital and Its Influencing Factors

更新时间：2023-04-16

- Blood Concentration Monitoring of Digoxin in A Hospital and Its Influencing Factors
- Vol. 22, Issue 8, Pages: 976-979(2022)
- 作者机构：
  
  空军特色医学中心药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.08.018
  CLC： R969.1
- Published：2022，
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HUANG Jinghui, ZHAO Yan, YANG Zhihui, et al. Blood Concentration Monitoring of Digoxin in A Hospital and Its Influencing Factors. [J]. 22(8):976-979(2022)
DOI：

HUANG Jinghui, ZHAO Yan, YANG Zhihui, et al. Blood Concentration Monitoring of Digoxin in A Hospital and Its Influencing Factors. [J]. 22(8):976-979(2022) DOI： 10.14009/j.issn.1672-2124.2022.08.018.

摘要

目的：探讨该院地高辛血药浓度(SDC)的影响因素。方法：基于系统查询方法，汇总2019年1月至2021年10月该院住院患者的SDC。采用回顾性研究方法，对使用地高辛治疗时进行治疗药物监测的住院患者的SDC、年龄、性别、肌酐清除率(CrCl)、血钾水平和联合用药情况等进行统计分析。结果：共纳入418例监测SDC的住院患者，平均SDC为(1.22±0.98) ng/mL;其中，171例患者(占40.91%)的SDC在正常范围内，200例患者(占47.85%)的SDC<0.50 ng/mL

47例患者(占11.24%)的SDC>1.75 ng/mL。患者性别、年龄、CrCl(<30 mL/min)及联合应用大环内酯类抗菌药物对SDC有显著影响(P<0.05)。结论：该院使用地高辛的患者中，仅约40%的患者SDC在有效治疗窗内，>45%的患者SDC低于最低有效治疗浓度，提示临床用药剂量较为保守。使用地高辛时，医师和临床药师应重点关注患者年龄、性别、CrCl以及与大环内酯类抗菌药物、排钾利尿剂等联合应用的情况，对SDC监测结果异常的患者及时调整用药剂量，提高临床治疗效果。

Abstract

OBJECTIVE: To probe into the influencing factors of digoxin blood concentration（SDC） in the hospital. METHODS: Based on the system query method

the SDC of inpatients in the hospital from Jan. 2019 to Oct. 2021 were summarized. SDC

age

gender

creatinine clearance rate（CrCl）

potassium level and drug combination of inpatients with therapeutic drug monitoring during digoxin treatment were statistically analyzed by retrospective study. RESULTS: A total of 418 inpatients monitored for SDC were included

and the average SDC was（1.22±0.98）ng/mL; among them

171 patients（40.91%） had SDC within the normal range

200 patients（47.85%） had SDC <0.50 ng/mL

and 47 patients（11.24%） had SDC >1.75 ng/mL. Gender

age

CrCl（<30 mL/min） and combined application with macrolide antibiotics had significant effects on SDC（P<0.05）. CONCLUSIONS: Only about 40% of patients using digoxin in this hospital had SDCs within the effective therapeutic window

and >45% had SDCs below the minimum effective therapeutic concentration

indicating that the clinical dose is conservative. When using digoxin

clinicians and clinical pharmacists should pay attention to patients’ age

gender

CrCl and combined application with macrolide antibiotics and potassium-removing diuretics

and timely adjust the dosage for patients with abnormal SDC monitoring results to improve the clinical treatment effect.

关键词

地高辛治疗药物监测年龄性别肌酐清除率联合用药

Keywords

DigoxinTherapeutic drug monitoringAgeGenderCreatinine clearanceDrug combination

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