Efficacy of Photodynamic Therapy Combined with Minocycline Hydrochloride in the Treatment of Severe Periodontitis and Its Effects on miR-193a and MCP-1 Levels

HUI Xinyu; ZHI Xiaolei; YU Xiaoyan; PEI Leijie; YAN Yuetong

doi:10.14009/j.issn.1672-2124.2022.08.013

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Efficacy of Photodynamic Therapy Combined with Minocycline Hydrochloride in the Treatment of Severe Periodontitis and Its Effects on miR-193a and MCP-1 Levels

更新时间：2023-04-16

- Efficacy of Photodynamic Therapy Combined with Minocycline Hydrochloride in the Treatment of Severe Periodontitis and Its Effects on miR-193a and MCP-1 Levels
- Vol. 22, Issue 8, Pages: 955-959(2022)
- 作者机构：
  
  1. 开滦总医院口腔科
  2. 华北医疗健康集团峰峰总医院北院区口腔科
  3. 华北医疗健康集团峰峰总医院南院区口腔科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.08.013
  CLC： R781.42
- Published：2022，
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HUI Xinyu, ZHI Xiaolei, YU Xiaoyan, et al. Efficacy of Photodynamic Therapy Combined with Minocycline Hydrochloride in the Treatment of Severe Periodontitis and Its Effects on miR-193a and MCP-1 Levels. [J]. 22(8):955-959(2022)
DOI：

HUI Xinyu, ZHI Xiaolei, YU Xiaoyan, et al. Efficacy of Photodynamic Therapy Combined with Minocycline Hydrochloride in the Treatment of Severe Periodontitis and Its Effects on miR-193a and MCP-1 Levels. [J]. 22(8):955-959(2022) DOI： 10.14009/j.issn.1672-2124.2022.08.013.

摘要

目的：探讨光动力疗法联合盐酸米诺环素治疗重度牙周炎的疗效及对miR-193a、MCP-1水平的影响。方法：选取2019年6月至2021年6月开滦总医院收治的98例重度牙周炎患者作为研究对象，采用随机数字表法按1∶1的比例分为观察组、对照组，各49例。对照组患者采用盐酸米诺环素治疗，观察组患者采用光动力疗法联合盐酸米诺环素治疗。治疗4周，比较两组患者的疗效及不良反应发生情况，治疗前后的牙周指数[菌斑指数(PLI)、探诊深度(PD)、牙龈指数(GI)和探诊出血情况(BOP)]、咀嚼功能(咀嚼效率、咬合力)、龈沟液炎症因子[基质金属蛋白酶7(MMP-7)、单核细胞趋化蛋白-1(MCP-1)和可溶性细胞间黏附分子-1(sICAM-1)]水平、微小RNA-193a(miR-193a)水平、骨吸收标志物指标[骨钙素(BGP)、骨保护素(OPG)和Ⅰ型胶原交联氨基末端肽(NTX)]水平及口腔健康影响程度量表14(OHIP-14)评分。结果：观察组患者的总有效率为95.92%(47/49)

高于对照组的81.63%(40/49)

差异有统计学意义(P<0.05)。治疗后，两组患者GI、PLI、BOP和PD水平均较治疗前降低，且观察组患者较对照组更低；两组患者咀嚼效率、咬合力均较治疗前升高，且观察组患者较对照组更高，差异均有统计学意义(P<0.05)。治疗后，两组患者MMP-7、MCP-1、sICAM-1和NTX水平均较治疗前降低，且观察组患者较对照组更低；两组患者miR-193a、BGP和OPG水平均较治疗前升高，且观察组患者较对照组更高，差异均有统计学意义(P<0.05)。治疗后，两组患者OHIP-14评分均较治疗前降低，且观察组患者较对照组更低，差异有统计学意义(P<0.05);两组患者局部红肿、局部疼痛和局部刺激等不良反应发生率比较，差异均无统计学意义(P>0.05)。结论：光动力疗法联合盐酸米诺环素治疗重度牙周炎的效果显著，可有效改善患者的牙周指数，减轻牙周炎症及骨吸收，有助于患者口腔健康状况及咀嚼功能的改善，且安全性高。

Abstract

OBJECTIVE: To probe into the efficacy of photodynamic therapy combined with minocycline hydrochloride in the treatment of severe periodontitis and its effects on miIR193 a and MCP-1 levels. METHODS: Totally 98 patients with severe periodontitis admitted into Kailuan General Hospital from Jun. 2019 to Jun. 2021 were selected and divided into observation group and control group via random number table

with 49 cases in each group. The control group was treated with minocycline hydrochloride

and the observation group was given photodynamic therapy combined with minocycline hydrochloride. After 4 weeks of treatment

the efficacy and incidences of adverse drug reactions

the periodontal index [plaque index（PLI）

probing depth（PD）

gingival index（GI） and bleeding of probing（BOP）]

masticatory function（masticatory efficiency

bite force）

gingival crevicular fluid inflammation factors [matrix metalloproteinase-7（MMP-7）

monocyte chemoattractant protein-1（MCP-1）

soluble intercellular adhesion molecule-1（sICAM-1）]

micro RNA-193 a（miR-193 a）

bone resorption markers [osteocalcin（BGP）

osteoprotegerin（OPG）

type I collagen cross-linked amino terminal peptide（NTX）]

oral health impact scale 14（OHIP-14） score were compared between two groups. RESULTS: The total effective rate of observation group was 95.92%（47/49）

which was higher than that of the control group（81.63%

40/49）

with statistically significant difference（P<0.05）. After treatment

the GI

PLI

BOP and PD levels of both groups were decreased

and those of the observation group were lower than the control group; the masticatory efficiency and bite force of both groups were increased

and those of the observation group were higher than the control group

with statistically significant differences（P<0.05）. After treatment

the MMP-7

MCP-1

sICAM-1 and NTX levels were decreased

and those of the observation group were lower than the control group; the miR-193 a

BGP and OPG levels were increased

and those of the observation group were higher than the control group

with statistically significant differences（P<0.05）. After treatment

the OHIP-14 scores of both groups were decreased

and that of the observation group was lower than the control group

with statistically significant difference（P<0.05）; the differences in the comparison of incidences of adverse drug reactions including local swelling

local pain and local stimulation were not statistically significant between two groups（P>0.05）. CONCLUSIONS: The efficacy of photodynamic therapy combined with minocycline hydrochloride in the treatment of severe periodontitis is remarkable

which can effectively improve periodontal index

relieve periodontal inflammation and bone resorption

contribute to the promotion of patients’ oral health and chewing function

with high safety.

关键词

光动力疗法骨吸收重度牙周炎炎症盐酸米诺环素牙周指数

Keywords

Photodynamic therapyBone resorptionSevere periodontitisInflammationMinocycline hydrochloridePeriodontal index

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