Effects of Gastrodin Combined with Anisomine Hydrobromate on Neurological Function in the Elderly with Cerebral Small Vessel Disease and Cognitive Dysfunction

SHE Saihong; MA Jingjing; ZHANG Feng; LIU Pei

doi:10.14009/j.issn.1672-2124.2022.08.008

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Effects of Gastrodin Combined with Anisomine Hydrobromate on Neurological Function in the Elderly with Cerebral Small Vessel Disease and Cognitive Dysfunction

更新时间：2023-04-16

- Effects of Gastrodin Combined with Anisomine Hydrobromate on Neurological Function in the Elderly with Cerebral Small Vessel Disease and Cognitive Dysfunction
- Vol. 22, Issue 8, Pages: 931-934(2022)
- 作者机构：
  
  1. 河北省第八人民医院急诊科
  2. 保定市第二中心医院神经内科
  3. 石家庄市第五医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.08.008
  CLC： R743;R749.1
- Published：2022，
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SHE Saihong, MA Jingjing, ZHANG Feng, et al. Effects of Gastrodin Combined with Anisomine Hydrobromate on Neurological Function in the Elderly with Cerebral Small Vessel Disease and Cognitive Dysfunction. [J]. 22(8):931-934(2022)
DOI：

SHE Saihong, MA Jingjing, ZHANG Feng, et al. Effects of Gastrodin Combined with Anisomine Hydrobromate on Neurological Function in the Elderly with Cerebral Small Vessel Disease and Cognitive Dysfunction. [J]. 22(8):931-934(2022) DOI： 10.14009/j.issn.1672-2124.2022.08.008.

摘要

目的：探讨天麻素联合氢溴酸樟柳碱对老年脑小血管病(CSVD)认知功能障碍患者神经功能的影响。方法：前瞻性选取2019年8月至2020年12月河北省第八人民医院收治的老年CSVD认知功能障碍患者104例，依据不同的给药方式分为对照组和研究组，各52例。两组患者先行常规治疗，对照组患者在常规治疗基础上口服氢溴酸樟柳碱片，研究组患者在对照组治疗基础上采用天麻素肌内注射，两组患者均治疗1个月。检测两组患者治疗前后的神经功能相关指标和炎症因子的表达水平，并进行简易精神状态检查量表(MMSE)、蒙特利尔认知评测量表(MoCA)评定，统计两组患者的总有效率和不良反应发生率。结果：两组患者治疗后脑源性神经营养因子(BDNF)表达，MMSE、MoCA评分明显高于治疗前；神经元特异性烯醇化酶(NSE)、中枢神经特异蛋白(S100β)、白细胞介素6(IL-6)和同型半胱氨酸(Hcy)表达水平明显低于治疗前，差异均有统计学意义(P<0.05)。研究组患者治疗后的BDNF表达，MMSE、MoCA评分明显高于对照组；NSE、S100β、IL-6和Hcy表达水平明显低于对照组，差异均有统计学意义(P<0.05)。研究组患者的总有效率为94.23%(49/52)

明显高于对照组的67.31%(35/52)

差异有统计学意义(P<0.05)。研究组、对照组患者的不良反应发生率分别为13.46%(7/52)、9.62%(5/52)

两组的差异无统计学意义(P>0.05)。结论：采用天麻素联合氢溴酸樟柳碱治疗老年CSVD认知功能障碍患者，可有效改善患者的神经功能以及认知功能，临床效果较好。

Abstract

OBJECTIVE: To probe into the effects of gastrodin combined with anisomine hydrobromate on neurological function in the elderly with cerebral small vessel disease（CSVD） and cognitive dysfunction. METHODS: A total of 104 elderly patients with CSVD and cognitive dysfunction admitted into the Eighth People’s Hospital of Hebei from Aug. 2019 to Dec. 2020 were prospectively extracted to be divided into the control group and the study group according to different administration methods

with 52 cases in each group. Both groups were given routine treatment

the control group was given oral Anisodine hydrobromide tablets on the basis of routine treatment

while the study group received intramuscular injection of gastrodin on the basis of the control group. Both groups were treated for 1 month. Expression levels of neurofunctional indicators and inflammatory factors were detected before and after treatment in two groups

and the mini-mental state examination（MMSE） and montreal cognitive assessment（MoCA） were evaluated. The total effective rate and incidence of adverse drug reactions in two groups were statistically analyzed. RESULTS: The expression of brain-derived neurotrophic factor（BDNF）

MMSE and MoCA scores in both groups after treatment were significantly higher than those before treatment; expression levels of neuron-specific enolase（NSE）

central nervous system-specific protein（S100β）

interleukin-6（IL）-6 and homocysteine（Hcy） were significantly lower than those before treatment

and the differences were statistically significant（P<0.05）. The expression of BDNF

MMSE and MoCA scores in the study group were significantly higher than those in the control group after treatment; expression levels of NSE

S100β

IL-6 and Hcy were significantly lower than those in the control group

and the differences were statistically significant（P<0.05）. The total effective rate of the study group was 94.23%（49/52）

significantly higher than 67.31%（35/52） of the control group

the difference was statistically significant（P<0.05）. The incidence of adverse drug reactions in the study group and the control group were respectively 13.46%（7/52） and 9.62%（5/52）

with no statistically significant difference（P>0.05）. CONCLUSIONS: Gastrodin combined with anisouline hydrobromate in the treatment of the elderly with CSVD and cognitive dysfunction can effectively improve the neurological function and cognitive function of patients

and the clinical effect is significant.

关键词

天麻素氢溴酸樟柳碱老年脑小血管病认知功能障碍神经功能

Keywords

GastrodinAnisodine hydrobromideCerebral small vessel disease and cognitive dysfunctionNeurological function

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